Differential N-Glycosylation Patterns in Lung Adenocarcinoma Tissue

Journal of Proteome Research
L Renee RuhaakSuzanne Miyamoto

Abstract

To decrease the mortality of lung cancer, better screening and diagnostic tools as well as treatment options are needed. Protein glycosylation is one of the major post-translational modifications that is altered in cancer, but it is not exactly clear which glycan structures are affected. A better understanding of the glycan structures that are differentially regulated in lung tumor tissue is highly desirable and will allow us to gain greater insight into the underlying biological mechanisms of aberrant glycosylation in lung cancer. Here, we assess differential glycosylation patterns of lung tumor tissue and nonmalignant tissue at the level of individual glycan structures using nLC-chip-TOF-MS. Using tissue samples from 42 lung adenocarcinoma patients, 29 differentially expressed (FDR < 0.05) glycan structures were identified. The levels of several oligomannose type glycans were upregulated in tumor tissue. Furthermore, levels of fully galactosylated glycans, some of which were of the hybrid type and mostly without fucose, were decreased in cancerous tissue, whereas levels of non- or low-galactosylated glycans mostly with fucose were increased. To further assess the regulation of the altered glycosylation, the glycomics data was...Continue Reading

References

Nov 28, 2000·International Journal of Cancer. Journal International Du Cancer·T TakahashiN Taniguchi
May 21, 2008·International Journal of Cancer. Journal International Du Cancer·Laura Muinelo-RomayAlmudena Fernández-Briera
Dec 23, 2008·Journal of Proteome Research·Mary Ann ComunaleAnand S Mehta
Feb 13, 2009·Proteomics·Carolin HuhnManfred Wuhrer
May 21, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Mengjun WangAnand S Mehta
Dec 5, 2009·Clinical Chemistry·Penelope M DrakeSusan J Fisher
Feb 16, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jun Lu, David G Grenache
Aug 3, 2010·Journal of Proteome Research·Maurice H J SelmanAndré M Deelder
Nov 26, 2010·Molecular & Cellular Proteomics : MCP·Maria Lorna A de LeozCarlito B Lebrilla
Jun 23, 2011·Cancer Informatics·Gwangsik ShinSeon-Young Kim
Jul 1, 2011·The New England Journal of Medicine·UNKNOWN National Lung Screening Trial Research TeamJoRean D Sicks
Jan 13, 2012·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Feb 11, 2012·Journal of Proteome Research·Danielle AldredgeCarlito B Lebrilla
Apr 12, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Anand MehtaTimothy Block
Apr 26, 2012·Glycoconjugate Journal·Manfred Wuhrer
May 11, 2012·Molecular & Cellular Proteomics : MCP·Crina I A BalogManfred Wuhrer
Jun 29, 2012·Electrophoresis·Yehia MechrefAhmed Hussein
Aug 28, 2012·Glycoconjugate Journal·Tharmala TharmalingamPauline M Rudd
Dec 26, 2012·Proceedings of the National Academy of Sciences of the United States of America·Chien-Yu ChenChi-Huey Wong
Jan 16, 2013·Nature Reviews. Urology·Sarah GilgunnRichard J O'Kennedy
Feb 1, 2013·Molecular & Cellular Proteomics : MCP·L Renee RuhaakCarlito B Lebrilla
Mar 26, 2013·Analytical and Bioanalytical Chemistry·L Renee RuhaakKyoungmi Kim
May 4, 2013·Proteomics. Clinical Applications·L Renee RuhaakSuzanne Miyamoto
Jul 31, 2013·International Journal of Molecular Sciences·Radka SaldovaPauline M Rudd
Dec 18, 2013·Proteomics·Maja N ChristiansenNicolle H Packer
Feb 22, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kyoungmi KimGary S Leiserowitz

❮ Previous
Next ❯

Citations

Apr 18, 2016·Molecular Aspects of Medicine·Ian LokeMorten Thaysen-Andersen
May 18, 2016·Biochemical and Biophysical Research Communications·Mengjun WangAnand Mehta
Jun 7, 2018·Scientific Reports·Margaret DohertyPauline M Rudd
Aug 15, 2019·Biological Reviews of the Cambridge Philosophical Society·Harry C TjondroMorten Thaysen-Andersen
Dec 22, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xia ZouYan Zhang
Oct 20, 2018·Current Medicinal Chemistry·Miklós SzabóEszter Csánky
Jan 9, 2019·Frontiers in Oncology·Liyuan JiaJihong Cui
Mar 27, 2020·Scientific Reports·Nan JiaRichard D Cummings
Aug 15, 2019·Molecular & Cellular Proteomics : MCP·Elisha GoonatillekeMariana Barboza
Jan 8, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Erika LattováMikuláš Popovič
Aug 7, 2017·Biomedit︠s︡inskai︠a︡ khimii︠a︡·S E NovikovaA I Archakov
Jan 7, 2021·Omics : a Journal of Integrative Biology·Medi KoriKazim Yalcin Arga
Oct 22, 2020·Molecular & Cellular Proteomics : MCP·Fanny BoyavalBram Heijs
Feb 11, 2021·Mass Spectrometry Reviews·Milani W PatabandigeHeather Desaire
Nov 1, 2019·Molecular & Cellular Proteomics : MCP·Elisha GoonatillekeMariana Barboza
Apr 4, 2020·Clinica Chimica Acta; International Journal of Clinical Chemistry·Andras KomaromyAndras Guttman
Feb 14, 2021·Molecular & Cellular Proteomics : MCP·Fanny BoyavalBram Heijs
Jun 18, 2016·Journal of Proteome Research·Erika LattováMikuláš Popovič
Mar 20, 2018·Chemical Reviews·L Renee RuhaakCarlito B Lebrilla
Mar 20, 2019·Journal of Proteome Research·Qinying LiGuangli Yu
Mar 18, 2017·ACS Chemical Biology·Aime Lopez AguilarPeng Wu
Mar 24, 2018·Bioconjugate Chemistry·Aime Lopez AguilarPeng Wu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.