PMID: 11319766Apr 25, 2001Paper

Differential NF-kappa B regulation of bcl-x gene expression in hippocampus and basal forebrain in response to hypoxia

Journal of Neuroscience Research
J QiuJ R Perez-Polo

Abstract

Cell death often occurs after hypoxic/ischemic injury to the central nervous system. Changes in levels of the anti-apoptotic Bcl-X(L) protein may be a determining factor in hypoxia-induced neuronal apoptosis. The transcription factor NF-kappa B regulates bcl-x gene expression. In this study, we examined the role of NF-kappa B in the regulation of bcl-x in hypoxia-induced cell death. Rat hippocampus and basal forebrain tissues were collected at different time points after hypoxia (7%O(2), 93% N(2) for 10 or 20 min). We found that 1) hypoxia induced apoptosis in the hippocampus and basal forebrain; 2) the NF-kappa B dimers c-Rel/p50 and p50/p50 bound to the bcl-x promoter NF-kappa B sequence (CS4) in the hippocampus, but only p50/p50 bound to the CS4 sequence in the basal forebrain and hypoxia-induced differential binding patterns of c-Rel/p50 and p50/p50 correlated with the bcl-x expression pattern in the hippocampus; 3) the hypoxia-induced patterns of binding of c-Rel/p50 to the bcl-x promoter CS4 sequence were different from those to the IgG-kappa B enhancer sequence, whereas those of p50/p50 were similar to both sequences; 4) nuclear protein levels of c-Rel, but not p50, correlated with the c-Rel/p50 DNA binding patterns to t...Continue Reading

References

Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·N D PerkinsG J Nabel
Sep 7, 1995·Annals of the New York Academy of Sciences·S JungY Ben-Neriah
Oct 22, 1993·Cell·D M HockenberyS J Korsmeyer
Nov 10, 1995·The Journal of Biological Chemistry·K N SchmidtP A Baeuerle
Jul 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P B KirschnerM F Beal
Jan 26, 1995·Nature·C W MüllerS C Harrison
Jan 1, 1994·Annual Review of Cell Biology·U SiebenlistK Brown
Dec 1, 1995·Annals of Neurology·D E Bredesen
Mar 15, 1996·The Journal of Biological Chemistry·A J MinnC B Thompson
Jul 1, 1996·The Journal of Cell Biology·S GrimmK Schulze-Osthoff
Nov 1, 1996·Brain Research. Molecular Brain Research·J HonkaniemiF R Sharp
Jan 23, 1997·Nature·A J MinnC B Thompson
Feb 1, 1997·Current Biology : CB·V R Baichwal, P A Baeuerle
Jun 24, 1997·Proceedings of the National Academy of Sciences of the United States of America·S KharbandaD Kufe
Jan 24, 1998·Brain Research·E P DixonS P Little
Jan 28, 1998·Acta Neuropathologica·I FerrerJ Ballabriga
Aug 13, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F J AntonawichJ N Davis
Aug 26, 1998·The Journal of Experimental Medicine·T C WenM Sakanaka
Dec 3, 1998·The Journal of Clinical Investigation·L GuedezM Stetler-Stevenson
Dec 4, 1998·Stroke; a Journal of Cerebral Circulation·M R PuleraC G Wasterlain
Jan 5, 1999·The Journal of Experimental Medicine·T HettmannJ M Leiden
Apr 14, 1999·Cell Death and Differentiation·M Grilli, M Memo
Aug 4, 1999·Proceedings of the National Academy of Sciences of the United States of America·H H LeeG Cheng
Mar 25, 2000·Molecular and Cellular Biology·C ChenC Gélinas

❮ Previous
Next ❯

Citations

Oct 23, 2002·Journal of Neuroscience Research·LiQi TongJ Regino Perez-Polo
Mar 27, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Seth Love
May 20, 2009·Journal of Neuroinflammation·Xianrong R MaoSteven W Barger
Jul 5, 2013·PLoS Biology·So Hee DhoSteven J Weintraub
Mar 9, 2013·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Smitha K InfanteJ R Perez-Polo
Sep 1, 2004·Biochimica Et Biophysica Acta·María Teresa RoncoCristina Ester Carnovale
Nov 6, 2003·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Xiaoming HuJ Regino Perez-Polo
Jul 27, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yun Seon SongPak H Chan
Apr 1, 2006·Journal of Neurochemistry·Paul T MassaSteven W Barger
Jun 14, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mohan R K DasuJ Regino Perez-Polo
Jun 16, 2004·Journal of Neuroscience Research·Jingxin QiuJ Regino Perez-Polo
Feb 10, 2010·Journal of Neuroscience Research·Diana Carolina FerrariJ Regino Perez-Polo
Apr 26, 2011·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·J Regino Perez-PoloHarriet C Rea
Jan 14, 2012·The Biochemical Journal·Ning LiuXiaoying Wang
Oct 31, 2012·Neuropathology and Applied Neurobiology·Y-Y ZouE-A Ling
Apr 19, 2002·The Journal of Pharmacology and Experimental Therapeutics·Justin McInnisKenneth M Johnson
Oct 9, 2007·Journal of Neuroscience Research·Danny Salah RafatiJ Regino Perez-Polo
Jul 21, 2006·European Journal of Pharmacology·Marina Pizzi, Pierfranco Spano
Sep 26, 2006·Biochemical Pharmacology·Sylvie Mémet

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis