PMID: 9184992Jun 16, 1997Paper

Differential number of glycine- and GABA-immunopositive neurons and terminals in the deep cerebellar nuclei of normal and Purkinje cell degeneration mutant mice

The Journal of Comparative Neurology
J Bäurle, U Grüsser-Cornehls

Abstract

The total number of glycine-immunopositive (Gly+) neurons in the deep cerebellar nuclei (DCN) was quantified under normal conditions in wild-types (B6C3Fe) and compared with the Purkinje cell-deprived situation in Purkinje cell degeneration (PCD)-mutants by using an unbiased stereological method, the disector. In addition, the size and density of Gly+ terminals, the number of gamma-aminobutyric acid immunopositive (GABA+) somata and the somatal colocalization of Gly and GABA were determined. In both wild-types and PCD mutants, Gly+ somata are distributed relatively homogeneously among the different subdivisions of the DCN. However, in the complete volume of the DCN, which is reduced in PCD mutants by 52%, 8,582 Gly+ neuronal somata are present in wild-types and 14,637 in PCD mutants, which corresponds to an increase of 70.5% in the mutant. In contrast, the total number of GABA+ somata is almost the same in wild-types (16,713) and in PCD mutants (15,339). The number of neurons that colocalize both Gly and GABA is again almost identical in wild-types (3,976) and PCD mutants (3,861). Moreover, the size and number of Gly+ terminals contacting DCN neurons of PCD mutants are increased significantly compared to the wild-types. These d...Continue Reading

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Citations

Aug 14, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Martha W BagnallSascha du Lac
Oct 15, 2009·The Cerebellum·Marylka Uusisaari, Thomas Knöpfel
Dec 1, 2010·The Cerebellum·Marylka Uusisaari, Thomas Knöpfel
Oct 2, 2002·The Journal of Comparative Neurology·Fahad SultanPeter Thier
Mar 25, 2009·Neuroscience·S-H ChungR Hawkes
Feb 1, 2008·Neuropharmacology·Christine M Pedroarena, Susanne Kamphausen
May 1, 2013·The Journal of Comparative Neurology·Ramón AnadónFátima Adrio
Mar 26, 1998·The Journal of Comparative Neurology·J BäurleU Grüsser-Cornehls
Sep 9, 2011·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Gene J Blatt, S Hossein Fatemi
Nov 28, 2002·The Journal of Comparative Neurology·Fahad SultanPeter Thier
Jan 16, 2008·The Journal of Comparative Neurology·Verona Villar-CerviñoMaría Celina Rodicio
Apr 10, 2009·Autism Research : Official Journal of the International Society for Autism Research·Jane YipGene J Blatt
May 9, 2009·The Cerebellum·Kejian ChenTodd W Preston
Feb 11, 2010·The Cerebellum·Mario Manto, Nordeyn Oulad Ben Taib
Dec 15, 2015·The Cerebellum·Adrian Handforth
Dec 25, 2015·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Michelle Y ChengGary K Steinberg

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