Differential ontogenesis of three DOI-induced behaviors in mice

Physiology & Behavior
N A DarmaniC F Gerdes

Abstract

Our previous studies have shown that intraperitoneal administration of DOI [(+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane] simultaneously produces the head-twitch and ear-scratch responses (HTR and ESR, respectively) in mice via activation of 5-HT2A receptors. In the present study, we have investigated the ontogeny of these DOI-induced behaviors in both male and female mice across a wide age range (i.e., postnatal days 7, 14, 18, 22, 28, 35, 42, 63, 120, and 180). We also measured the effects of DOI on the locomotor activity of these mice. In addition to the vehicle, 2 doses of DOI (1 and 2.5 mg/kg) were used in age-matched different male and female groups. The age of onset for significant production of HTR and ESR by both doses of DOI were between postpartum days 14-18 and 18-22, respectively. Maximal HTR frequency to both doses of DOI (66 and 94 HTRs) occurred on postpartum day 28. Thereafter, the HTR frequency tended to decrease with increasing age, but the attenuation did not attain significance. On the other hand, maximal ESR score (37 and 60 ESRs) generally developed between postpartum days 22-35 for the cited doses of DOI. After 35 days of age, the ESR frequency dramatically decreased and, by postnatal day 180, no ...Continue Reading

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Citations

Mar 22, 2005·European Journal of Pharmacology·Mercedes DelgadoJosé A Fuentes
Dec 4, 2003·Pharmacology, Biochemistry, and Behavior·Renee L Hayslett, Yousef Tizabi
Aug 2, 2002·Pharmacology, Biochemistry, and Behavior·Mike F HawkinsThomas S Guillot
Jul 23, 2003·Pharmacology, Biochemistry, and Behavior·Tamara L DoremusLinda Patia Spear
May 19, 2000·Neuroscience and Biobehavioral Reviews·L P Spear
Jul 25, 2003·Brain Research. Molecular Brain Research·Karin C WeissSabine P Cordes
Aug 22, 2001·Progress in Neuro-psychopharmacology & Biological Psychiatry·Y TizabiN A Darmani
Apr 15, 2006·Development and Psychopathology·Jackie K GollanEmil F Coccaro
Mar 27, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Adam L HalberstadtSusan B Powell
Nov 19, 2008·Developmental Psychobiology·Tatiana ManriqueMilagros Gallo
Jul 19, 2014·Behavioural Brain Research·Adam L Halberstadt
Oct 19, 2017·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Ankit SoodVidita A Vaidya
Oct 5, 2019·Scientific Reports·Mario de la Fuente RevengaJavier González-Maeso
Nov 12, 2021·Frontiers in Endocrinology·Atsuko Hayata-TakanoHitoshi Hashimoto

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