PMID: 7518466Jul 1, 1994Paper

Differential organization of desmin and vimentin in muscle is due to differences in their head domains

The Journal of Cell Biology
R B Cary, M W Klymkowsky

Abstract

In most myogenic systems, synthesis of the intermediate filament (IF) protein vimentin precedes the synthesis of the muscle-specific IF protein desmin. In the dorsal myotome of the Xenopus embryo, however, there is no preexisting vimentin filament system and desmin's initial organization is quite different from that seen in vimentin-containing myocytes (Cary and Klymkowsky, 1994. Differentiation. In press.). To determine whether the organization of IFs in the Xenopus myotome reflects features unique to Xenopus or is due to specific properties of desmin, we used the injection of plasmid DNA to drive the synthesis of vimentin or desmin in myotomal cells. At low levels of accumulation, exogenous vimentin and desmin both enter into the endogenous desmin system of the myotomal cell. At higher levels exogenous vimentin forms longitudinal IF systems similar to those seen in vimentin-expressing myogenic systems and massive IF bundles. Exogenous desmin, on the other hand, formed a reticular IF meshwork and non-filamentous aggregates. In embryonic epithelial cells, both vimentin and desmin formed extended IF networks. Vimentin and desmin differ most dramatically in their NH2-terminal "head" regions. To determine whether the head region w...Continue Reading

References

Feb 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·B Vogelstein, D Gillespie
Sep 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·M W KlymkowskyL A Maynell
Nov 1, 1992·The Journal of Cell Biology·J A DentM W Klymkowsky
Apr 1, 1992·Experimental Cell Research·J G Tidball
Apr 1, 1991·Acta Paediatrica Japonica; Overseas Edition·H B Sarnat
Aug 25, 1989·Nucleic Acids Research·A HemsleyD J Galas
Jan 1, 1989·Journal of the Neurological Sciences·J F PellissierD Figarella
Jan 1, 1988·Journal of Molecular Evolution·G S CrossH R Woodland
Mar 1, 1972·Journal of the Neurological Sciences·S A ShafigA T Milhorat
Mar 1, 1983·Muscle & Nerve·A FidzianskaU Langenbeck
Feb 1, 1984·Journal of Biomechanical Engineering·A J Brady
Jun 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·P M SteinertR D Goldman
Jun 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·R A Quinlan, W W Franke
Jan 1, 1982·Cold Spring Harbor Symposia on Quantitative Biology·H HoltzerY Toyama
Jan 1, 1980·Virchows Archiv. A, Pathological Anatomy and Histology·A PorteA Batzenschlager
Apr 1, 1994·Differentiation; Research in Biological Diversity·R B Cary, M W Klymkowsky
Jan 1, 1993·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·H H Goebel, A Bornemann
Sep 1, 1993·The Journal of Cell Biology·M K LeeD W Cleveland
Apr 1, 1993·The Journal of Cell Biology·O OharaT Kitamura
Jun 1, 1993·European Journal of Biochemistry·F A van de KlundertH Bloemendal

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Citations

Jan 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T NikiA Geerts
Dec 1, 1996·Cancer Metastasis Reviews·M W Klymkowsky
Feb 1, 1995·Current Opinion in Cell Biology·M W Klymkowsky
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·A Karnovsky, M W Klymkowsky
Mar 21, 1998·Nucleic Acids Research·R B CaryD J Chen
Jan 19, 1999·Annual Review of Cell and Developmental Biology·P GunningE Hardeman
Jun 6, 2012·PloS One·Alexandra TraisterJohn G Coles
Jun 15, 2015·Journal of Comparative Pathology·R SirriG Sarli
Mar 27, 2007·Differentiation; Research in Biological Diversity·Alexandra HöllriglGeorg Weitzer
Aug 3, 2016·Scientific Reports·Liana C Boraas, Tabassum Ahsan
Jul 12, 2005·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C S MermelsteinM L Costa
Jan 17, 2003·Cell Motility and the Cytoskeleton·Kurt HauboldMichael W Klymkowsky
Jul 17, 2020·Frontiers in Cell and Developmental Biology·Jun HeDaiwen Chen

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