Differential Pattern of Interhemispheric Connections Between Homotopic Layer V Regions in the Forelimb Representation in Rat Barrel Field Cortex

The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology
Tina M Decosta-FortuneRobert S Waters

Abstract

Layer V neurons in forelimb and shoulder representations in rat first somatosensory cortex (SI) project to the contralateral SI. However, few studies have addressed whether projections from specific subregions of the forelimb representation, namely forepaw, wrist, or forearm, terminate at homotopic sites in the contralateral SI. Neuroanatomical retrograde (cholera toxin B subunit [CT-B]) or anterograde (biodextran amine [BDA]) tracers were injected into physiologically identified sites in layer V in specific forelimb and/or shoulder representations in SI to examine the projection to contralateral SI in young adult rats (N = 17). Injection and target sites were flattened and cut in a tangential plane to relate labeling to the body map or cut along a coronal plane to relate labeling to cortical layers. Results indicate that layer V neurons project to cortical laminae II-VI in contralateral SI, with the densest labeling in layer V followed by layer III. In contrast, layer V neurons send sparse projections to layer IV. Furthermore, layer V neurons in wrist, forearm, and shoulder project to homotopic sites in contralateral layer V, while neurons in the forepaw representation project largely to sites in perigranular and dysgranular c...Continue Reading

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