PMID: 8597602Mar 1, 1996Paper

Differential patterns of antioxidant enzyme mRNA expression in guinea pig lung and liver during development

Biochimica Et Biophysica Acta
H T YuanF J Kelly

Abstract

cDNA clones for guinea pig antioxidant enzymes, copper-zinc (Cu-Zn) and manganese (Mn-) superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) were isolated by reverse transcription (RT)-polymerase chain reaction (PCR) cloning, to explore the mechanism regulating the differential expression of antioxidant enzymes (AOEs) in guinea pig lung and liver, during development. Increases in MnSOD, CAT and GPx mRNA expression in lung and, MnSOD mRNA in liver, were seen during the final period of gestation, whereas CuZnSOD and CAT mRNA expression in liver, which was constant during gestation, increased in the postnatal period. In lung, CuZnSOD mRNA level decreased just prior to birth while in liver, GPx mRNA expression declined markedly over the last third of gestation. In lung, while the mRNA levels of MnSOD, CAT, and GPx increased pre-natally, they declined following birth. In contrast, the postnatal increase in mRNA for CuZnSOD and CAT and the prenatal increase in MnSOD mRNA expression in liver remained at least to adolescence. In adolescent guinea pigs, CuZnSOD and CAT mRNA were most abundantly expressed in liver, while MnSOD and GPx mRNA were most abundant in heart and spleen, respectively. These results demonstr...Continue Reading

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Citations

Mar 25, 2005·Anatomy and Embryology·In-Jeoung BaekSang-Yoon Nam
May 1, 1997·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·X G LeiK R Roneker
Sep 11, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Adeleye J AfolayanGirija G Konduri
Jun 11, 2003·American Journal of Respiratory and Critical Care Medicine·Vuokko L Kinnula, James D Crapo
Dec 9, 1998·American Journal of Respiratory Cell and Molecular Biology·T M AsikainenV L Kinnula
Apr 17, 2007·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·C L XuJ Feng
Jan 9, 2014·International Journal of Radiation Biology·Chi ZhangXuemian Lu
Feb 16, 2005·Toxicology and Applied Pharmacology·Tiina M Asikainen, Carl W White
May 4, 2011·Cell Biochemistry and Function·Yazeed A Al-Sheikh, Hazem K Ghneim
Sep 13, 2002·Pediatrics International : Official Journal of the Japan Pediatric Society·Yumi KonoYuzuru Otsuka

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