Abstract
pp 120, a plasma membrane glycoprotein expressed by hepatocytes, is a substrate of the insulin receptor tyrosine kinase. Since insulin-like growth factor-1 (IGF-1) and insulin receptors are structurally homologous, we investigated whether pp120 is also a substrate of the IGF-1 receptor tyrosine kinase. IGF-1 receptor failed to phosphorylate pp120 in response to IGF-1 in stably transfected NIH 3T3 fibroblasts. However, replacement of the C-terminal domain of the beta-subunit of the IGF-1 receptor with the corresponding fragment in the insulin receptor restored ligand-stimulated pp120 phosphorylation, suggesting that this domain plays a regulatory role in pp120 phosphorylation. Since pp120 is the first identified substrate specific for the insulin vis-à-vis the IGF-1 receptor tyrosine kinase, the pp120 signaling pathway may constitute a novel mechanism for the distinct cellular effects of insulin and IGF-1, the former being principally involved in metabolism, and the latter in mitogenesis.
References
Aug 19, 1991·FEBS Letters·T S PillayK Siddle
Apr 14, 1989·Biochemical and Biophysical Research Communications·M FanciulliN Perrotti
Mar 10, 1995·The Journal of Biological Chemistry·D Beitner-Johnson, D LeRoith
Oct 13, 1995·The Journal of Biological Chemistry·P FormisanoP Gorden
Jul 19, 1993·FEBS Letters·M Edlund, B Obrink
Jul 1, 1994·European Journal of Biochemistry·S GiorgettiE Van Obberghen
Oct 15, 1993·The Biochemical Journal·P H CheungS H Lin
Citations
May 8, 2000·Journal of Cellular Biochemistry·M BernierS Kole
Nov 20, 2008·Journal of Mammary Gland Biology and Neoplasia·Antonino Belfiore, Francesco Frasca
May 11, 2000·Molecular and Cellular Biology·P SoniS M Najjar
Jul 11, 2012·Journal of Signal Transduction·Barbara P Craddock, W Todd Miller
Jun 1, 2000·Bioscience, Biotechnology, and Biochemistry·H KatoD LeRoith
May 10, 2008·Archives of Physiology and Biochemistry·Haim WernerItay Bentov
Nov 13, 2013·Biochemical and Biophysical Research Communications·Myung-Ju OhByung H Jhun
Aug 15, 2002·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Jane J Kim, Domenico Accili
Nov 30, 1999·Molecular Cell Biology Research Communications : MCBRC·P SoniS M Najjar
Jun 24, 2014·Yonsei Medical Journal·Sayamaa LkhagvadorjMinseob Eom
Mar 27, 2004·Physiological Reviews·Anindita NandiDomenico Accili
May 28, 1998·The Journal of Biological Chemistry·S M NajjarM N Poy
Apr 11, 2019·Physiology·Sonia M Najjar, Germán Perdomo
Mar 7, 1998·The Journal of Biological Chemistry·J Wang, H Riedel
Nov 6, 2001·The Journal of Biological Chemistry·Matthew N PoySonia M Najjar
Aug 31, 2016·Oncotarget·Florian WegwitzAndrea Kristina Horst
Jul 19, 2001·Endocrinology·J J KimD Accili
Jan 5, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael Pollak
Jan 14, 2021·Cell and Tissue Research·Ashalyn P WattJulie A Sharp