Differential presentations, clinical courses, and survivals of osteosarcomas of the proximal humerus over other extremity locations

Annals of Surgical Oncology
Wan Hyeong ChoSoo-Yong Lee

Abstract

Although there are controversies about the prognosis of proximal humeral osteosarcoma, our previous study showed poor survival in those patients. In the present study, we undertook to determine why this site is associated with a poor outcome and to identify the clinicopathologic variables involved. The study cohort consisted of 36 proximal humeral and 341 other extremity American Joint Committee on Cancer (AJCC) stage II osteosarcomas. We examined the clinicopathologic differences between these osteosarcomas. The prognostic significances of factors identified for a proximal humoral location were evaluated by survival analysis of all 377 patients. Patients with a proximal humeral osteosarcoma had the following characteristics: a higher incidence of pathologic fracture (P\0.01), an osteolytic pattern on plain radiographs (P\0.01), an unusual pathological subtype (P = 0.01), poor histologic response (P\0.01), and an increased tumor-volume ratio (TVR) (P\0.01). Multivariate analysis revealed that a large tumor volume (P\0.01), an increase in tumor volume (P\0.01), and a poor histologic response to preoperative chemotherapy (P\0.01) independently predicted shorter metastasis-free survival. The association between proximal humeral os...Continue Reading

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Citations

Jun 18, 2014·ILAR Journal·Joelle M FengerWilliam C Kisseberth
Feb 28, 2014·Clinical Orthopaedics and Related Research·Dae-Geun JeonSang Hyun Cho
Sep 24, 2010·Der Orthopäde·P T Funovics, M Dominkus
Sep 29, 2015·Pediatric Radiology·Sireesha YedururiNajat C Daw
May 17, 2012·BMC Veterinary Research·Ilse BoermanJolle Kirpensteijn
Apr 10, 2018·SICOT-J·Amirhossein MisaghiAnna A Kulidjian
Dec 18, 2018·Journal of Cellular Biochemistry·Xianliang YangPanfeng Xu
Jan 11, 2019·Journal of Pediatric Hematology/oncology·Ahmed M MorsyHanan A Eltyb
May 21, 2019·Journal of Pediatric Hematology/oncology·Ahmed M MorsyMaha S El-Naggar
Aug 26, 2010·Expert Review of Anticancer Therapy·Dae-Geun Jeon, Won Seok Song
Dec 30, 2016·BMC Musculoskeletal Disorders·Lien-Hsiang ChungWei-Ming Chen
Dec 15, 2020·International Journal of Biological Macromolecules·Parisa Maleki DanaBahman Yousefi
Apr 22, 2021·Current Oncology Reports·Rebekah BelaynehKurt R Weiss

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