Abstract
Determination of the prevalence of liver disease caused by hepatitis C virus (HCV) of various genotypes helps provide an understanding of the virulences of these genotypes. Differences in the prevalences of these genotypes are known to exist in the various geographical regions of the world. Hence, we performed seroepidemiological and molecular epidemiological analyses of HCV in Surabaya, Indonesia. The prevalences of anti-HCV antibodies were 2.3, 76.3 and 64.7% in healthy blood donors, patients on maintenance hemodialysis, and patients with hepatocellular carcinoma (HCC), respectively. HCV-2a was the most common (52%) among the HCV clones obtained from blood donors; this was followed by HCV-1b (15%), HCV-1a (7%), and HCV-1d (7%), a unique Indonesian subtype. The high prevalence of HCV-2a in blood donors was further supported by serotyping analysis that could discriminate HCV type 2 (HCV-2a and -2b) from HCV type 1 (HCV-1a, -1b, and -1d). HCV-1a, -1b, and -1d were strongly associated with elevated serum alanine aminotransferase (ALT) levels in blood donors, suggesting a possibly more pathogenic feature of those subtypes than HCV-2a. In patients on maintenance hemodialysis, HCV-1a and -1b (each 31%) were among the most common sub...Continue Reading
References
Jun 20, 1992·Lancet·K KanaiH Okamoto
Aug 24, 1991·Lancet·G PozzatoK Kobayashi
Jan 1, 1995·Archives of Virology·D D ShuklaC W Ward
Mar 1, 1995·The Journal of General Virology·T ValliammaiT J Harrison
Jan 1, 1995·Microbiology and Immunology·C ApichartpiyakulH Hotta
Jan 1, 1994·Archives of Virology·H HottaM Homma
Oct 1, 1995·The Journal of General Virology·J MellorP Simmonds
Feb 1, 1995·Seminars in Liver Disease·J BukhR H Purcell
Feb 1, 1995·Journal of Virological Methods·S WidjajaS H Yap
Sep 1, 1994·Journal of Clinical Microbiology·C ApichartpiyakulH Hotta
Feb 1, 1995·Gastroenterology·S PolC Brechot
Jan 1, 1995·The Journal of General Virology·W K GreeneK W Yap
Dec 1, 1994·Journal of Clinical Microbiology·H HottaM Homma
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·H TokitaM Mayumi
Jan 1, 1994·Microbiology and Immunology·H DoiH Hotta
Jun 1, 1994·Journal of Medical Virology·S HadiwandowoM Mayumi
Oct 1, 1994·Journal of Virology·H MizushimaK Shimotohno
Jan 1, 1994·Journal of Clinical Microbiology·M PistelloM Tuoni
Mar 1, 1994·The Journal of General Virology·H OkamotoM Mayumi
Feb 1, 1994·Journal of Clinical Microbiology·G E KleterW G Quint
Apr 1, 1994·The Journal of General Virology·H TokitaM Mayumi
Nov 1, 1993·The Journal of General Virology·P SimmondsM S Urdea
May 1, 1993·Journal of Virology·A GrakouiC M Rice
Aug 1, 1993·Journal of Virology·M HijikataK Shimotohno
Feb 1, 1996·The Journal of General Virology·H TokitaM Mayumi
Jan 1, 1996·Microbiology and Immunology·Y KatayamaH Hotta
Mar 1, 1996·Journal of Clinical Microbiology·H DoiH Hotta
Citations
Sep 20, 2001·Memórias do Instituto Oswaldo Cruz·M A CarneiroC F Yoshida
Aug 9, 2003·Microbiology and Immunology·Kiyomasa OkaHak Hotta
Apr 6, 2013·Alimentary Pharmacology & Therapeutics·L H Nguyen, M H Nguyen
May 25, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·Andi UtamaSusan Tai
Sep 14, 2016·World Journal of Gastroenterology : WJG·Maria Inge LusidaYoshihiko Yano
Aug 2, 2000·Journal of Gastroenterology and Hepatology·J M KaldorP K Correll
Jul 27, 2006·Digestive Diseases and Sciences·Haldun SelcukSedat Boyacioglu
Jan 22, 2003·Journal of Gastroenterology and Hepatology·Robert Y M ChenStephen A Locarnini
Mar 24, 2007·Journal of Gastroenterology·Kyaw SoeTakehiko Koji
Apr 14, 2012·Journal of Medical Virology·Nungki AnggorowatiYoshitake Hayashi
Jan 5, 2002·Microbiology and Immunology·I YoshidaH Hotta
Dec 26, 2003·Microbiology and Immunology·Maria I LusidaHak Hotta
Mar 12, 2004·Nephrology·Seyed Moayed AlavianSadegh Ahrabi
Dec 25, 2013·PloS One·Tomohiro KotakiMasanori Kameoka
Aug 7, 2013·Journal of Medical Virology·Hanggoro Tri RinonceYoshitake Hayashi
Aug 30, 2013·Journal of Virology·Ling LuGuihua Chen
Oct 28, 1998·Environmental Health Perspectives·F J RomeroJ Romá
Mar 24, 2016·Japanese Journal of Infectious Diseases·Alfonsus Adrian HadikusumoYoshitake Hayashi
Apr 3, 1998·Microbiology and Immunology·Y KatayamaH Hotta
Dec 31, 1998·Free Radical Biology & Medicine·M J RomeroF J Romero
May 21, 2021·PloS One·Ahmad Adebayo IrekeolaRafidah Hanim Shueb
Oct 30, 2001·Journal of Clinical Microbiology·M I LusidaH Hotta
Oct 2, 2002·Journal of Clinical Microbiology·Satoshi OgataHak Hotta
Jul 5, 2003·Journal of Clinical Microbiology·Satoshi OgataHak Hotta
Jul 1, 1997·Journal of Virology·S MuramatsuH Hotta
Feb 3, 2000·Journal of Clinical Microbiology·R HandajaniH Hotta
Aug 5, 1999·Kidney International·S N NatovB J Pereira