Differential production of IL-12, IFN-alpha, and IFN-gamma by mouse dendritic cell subsets

The Journal of Immunology : Official Journal of the American Association of Immunologists
H HochreinMeredith O'Keeffe

Abstract

Dendritic cells (DC) not only stimulate T cells effectively but are also producers of cytokines that have important immune regulatory functions. In this study we have extended information on the functional differences between DC subpopulations to include differences in the production of the major immune-directing cytokines IL-12, IFN-alpha, and IFN-gamma. Splenic CD4(-)8(+) DC were identified as the major IL-12 producers in response to microbiological or T cell stimuli when compared with splenic CD4(-)8(-) or CD4(+)8(-) DC; however, all three subsets of DC showed similar IL-12 regulation and responded with increased IL-12 p70 production if IL-4 was present during stimulation. High level CD8 expression also correlated with extent of IL-12 production for DC isolated from thymus and lymph nodes. By using gene knockout mice we ruled out any role for CD8alpha itself, or of priming by T cells, on the superior IL-12-producing capacity of the CD8(+) DC. Additionally, CD8(+) DC were identified as the major producers of IFN-alpha compared with the two CD8(-) DC subsets, a finding that suggests similarity to the human plasmacytoid DC lineage. In contrast, the CD4(-)8(-) DC produced much more IFN-gamma than the CD4(-)8(+) or the CD4(+)8(-)...Continue Reading

References

Nov 1, 1992·The Journal of Experimental Medicine·V A WallaceT W Mak
Jan 1, 1992·Advances in Experimental Medicine and Biology·T W MakW P Fung-Leung
Oct 1, 1993·Pharmacology & Therapeutics·P Fitzgerald-Bocarsly
Apr 1, 1996·The Journal of Experimental Medicine·G Süss, K Shortman
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·T YoshimotoK Nakanishi
Mar 3, 1997·The Journal of Experimental Medicine·L BrunoH Spits
Mar 27, 1997·Nature·T SparwasserH Wagner
Apr 1, 1997·Immunological Reviews·R M SteinmanK Inaba
Mar 21, 1998·Journal of Immunological Methods·J L WhitelandT J Hill
Apr 1, 1998·Nature·J Banchereau, R M Steinman
Oct 2, 1998·Advances in Immunology·G Trinchieri
Feb 2, 1999·The Journal of Experimental Medicine·R Maldonado-LópezM Moser
Feb 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·B PulendranC R Maliszewski
Jun 22, 1999·The Journal of Experimental Medicine·T OhtekiS Koyasu
Dec 22, 1999·The Journal of Immunology : Official Journal of the American Association of Immunologists·T FukaoS Koyasu
Mar 8, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·D VremecK Shortman
Apr 28, 2000·International Immunology·V KroninK Shortman
Jun 10, 2000·Immunology and Cell Biology·V KroninA Kelso
Jul 19, 2000·The Journal of Experimental Medicine·N KadowakiY J Liu
Jul 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·U GrohmannP Puccetti
Aug 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·P KalińskiM L Kapsenberg
Dec 20, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A T KamathK Shortman

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Citations

Jun 4, 2002·Nature Medicine·Helmut ButzkuevenTrevor J Kilpatrick
Dec 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Javier ValenzuelaMatthew Mescher
Dec 24, 2002·Nature Immunology·Daniel M AndrewsMariapia A Degli-Esposti
Jun 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alexander D EdwardsCaetano Reis e Sousa
Jul 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christie L DoxseeRoss M Kedl
Oct 4, 2003·Journal of Leukocyte Biology·Kate SchroderDavid A Hume
Jan 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Aleksandar DakicLi Wu
Mar 25, 2004·Infection and Immunity·Tracey BaldwinEmanuela Handman
Oct 6, 2004·Expert Opinion on Biological Therapy·Hideho Okada, Ian F Pollack
Nov 18, 2004·Immunological Reviews·Christian BogdanUlrike Schleicher
Jul 29, 2005·Immunological Reviews·Guénolée Prioult, Cathryn Nagler-Anderson
Jan 31, 2006·Nature Medicine·Julien TaiebLaurence Zitvogel
Jul 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·R Lee ReinhardtRichard M Locksley
Oct 24, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gloria Martínez del HoyoPierre Aucouturier
Jan 24, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Steven R BeatySun-Sang J Sung
Jan 16, 2008·The Journal of Experimental Medicine·Mark A WalletRoland Tisch
Apr 9, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Annette M MarleauBhagirath Singh
Feb 15, 2008·Proceedings of the National Academy of Sciences of the United States of America·Ming Lee LinAndrew M Lew
Sep 10, 2008·Immunology and Cell Biology·Anna I ProiettoLi Wu
Dec 17, 2008·Mucosal Immunology·P Sathe, K Shortman
Mar 17, 2009·Experimental & Molecular Medicine·Ken ShortmanIrina Caminschi
Sep 9, 2008·World Journal of Gastroenterology : WJG·Jan Hendrik Niess
Aug 5, 2009·Current Protocols in Immunology·Kayo InabaCarine Brinster
Feb 18, 2009·Clinical and Experimental Immunology·M CernadasM B Brenner
Dec 19, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Trine N JørgensenLoren D Erickson
Feb 24, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zhengguo XiaoMatthew F Mescher
Mar 3, 2010·Immunological Reviews·Ken Shortman, William R Heath
Jul 21, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yifan ZhanAndrew M Lew
May 19, 2010·The Journal of Experimental Medicine·Sarah L JongbloedKristen J Radford
Dec 8, 2011·Journal of Leukocyte Biology·Shinji Kasahara, Edward A Clark
Apr 26, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Diana MittagLeonard C Harrison
Jun 11, 2011·European Journal of Immunology·Yifan ZhanAndrew M Lew
Jun 19, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Julie M CurtsingerMatthew F Mescher
Nov 19, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zoran V PopovicHermann-Josef Gröne
Jul 17, 2012·Nature Immunology·Jennifer C MillerUNKNOWN Immunological Genome Consortium
Sep 19, 2012·Proceedings of the National Academy of Sciences of the United States of America·Mireille H LahoudIrina Caminschi

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