Differential production of interleukin-6 and its close relation to liver metastasis in clones from murine P815 mastocytoma

Cancer Letters
H HojoY Hashimoto

Abstract

Interleukin-6 (IL-6)-producing abilities of plastic-adherent and plastic-non-adherent P815 clones were investigated in connection with the liver metastasis. Most adherent clones produced IL-6 at high level (over 10 ng/10(5) cells per 48 h), and they coincided with highly liver-metastatic clones. The remaining adherent and all the non-adherent clones tested produced IL-6 at low level (under 1.5 ng/10(5) cells), and they coincided with the low or non-liver-metastatic clones. The IL-6 production was greatly enhanced by IL-1 alpha, but not by IL-6, tumor necrosis factor-alpha or interferon-gamma.

References

Feb 20, 1992·International Journal of Cancer. Journal International Du Cancer·M R YoungJ M Bagash
Feb 1, 1991·International Journal of Cancer. Journal International Du Cancer·K TakedaK Kumagai
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·T IshibashiS A Burstein
Feb 1, 1988·The Journal of Experimental Medicine·A MuraguchiT Kishimoto
Jan 1, 1984·Cancer Metastasis Reviews·G J Gasic
Jun 1, 1993·Biulleten' eksperimental'noĭ biologii i meditsiny·N A KlimenkoE D Gol'dberg
May 1, 1993·The Journal of Experimental Medicine·P OroszD N Männel
Apr 1, 1996·The Tohoku Journal of Experimental Medicine·R SunY Hashimoto

❮ Previous
Next ❯

Citations

Dec 31, 2003·Journal of Neuroimmunology·Theoharis C Theoharides, David E Cochrane
Dec 29, 2006·Annals of the New York Academy of Sciences·Theoharis C Theoharides, Dimitrios Kalogeromitros
May 15, 2007·Immunological Reviews·Theoharis C TheoharidesDimitris Kalogeromitros

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.