Differential production of prostaglandins within the human uterus

M H Abel, R W Kelly


The ability of broken cell preparations of human endometrium, myometrium and a mixture of endometrium and myometrium to convert 14C arachidonic acid to prostaglandins (PG's) was compared. Endometrium metabolished arachidonic acid predominantly to a mixture of PGF2 alpha and PGE2. A similar weight of myometrium showed relatively little activity, the major product identified was 6 oxo PGF1 alpha. However, a combination of endometrium and myometrium showed an enhanced conversion of arachidonic acid to 6 oxo PGF1 alpha associated with a decreased production of PGF2 alpha and PGE2. This suggests that human endometrium and myometrium differ in their ability to metabolize arachidonic acid and in their ability to convert the endoperoxides formed, to PG's.


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Jan 1, 1987·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·M R RichardsonJ T Stull
Jan 1, 1987·Journal of Steroid Biochemistry·A R Fuchs
Mar 1, 1985·European Journal of Obstetrics, Gynecology, and Reproductive Biology·P MoonenM J Keirse
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Mar 1, 1990·Prostaglandins·A Aitokallio-Tallberg
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Jun 1, 1985·Prostaglandins, Leukotrienes, and Medicine·A JouanenA Crastes de Paulet
Mar 1, 1985·Prostaglandins, Leukotrienes, and Medicine·I T CameronD T Baird
Sep 1, 1986·Prostaglandins, Leukotrienes, and Medicine·O IshiharaK Satoh
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Jan 1, 1989·Prostaglandins, Leukotrienes, and Essential Fatty Acids·P V Peplow, P R Hurst
Dec 20, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Tamsin Lindstrom, Phillip Bennett
Dec 20, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Leslie Myatt, Stephen J Lye
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