Differential Prognostic Effect Between First- and Second-Generation Drug-Eluting Stents in Coronary Bifurcation Lesions: Patient-Level Analysis of the Korean Bifurcation Pooled Cohorts.

JACC. Cardiovascular Interventions
Joo Myung LeeHyo-Soo Kim

Abstract

The purpose of this study was to investigate the differential clinical outcomes after percutaneous coronary intervention (PCI) for coronary bifurcation lesions with 1- or 2-stenting techniques using first- or second-generation drug-eluting stents (DES). The 2-stenting technique has been regarded to have worse clinical outcomes than the 1-stenting technique after bifurcation PCI with first-generation DES. However, there has been a paucity of data comparing the 1- and 2-stenting techniques with the use of second-generation DES. Patient-level pooled analysis was performed with 3,162 patients undergoing PCI using first- or second-generation DES for bifurcation lesions from the "Korean Bifurcation Pooled Cohorts" (COBIS [Coronary Bifurcation Stenting] II, EXCELLENT [Registry to Evaluate Efficacy of Xience/Promus Versus Cypher in Reducing Late Loss After Stenting], and RESOLUTE-Korea [Registry to Evaluate the Efficacy of Zotarolimus-Eluting Stent]). The 3-year clinical outcomes were compared between 1- and 2-stenting techniques, stratified by the type of DES. With first-generation DES, rates of target lesion failure (TLF) or patient-oriented composite outcome (POCO) (a composite of all death, any myocardial infarction, any repeat rev...Continue Reading

Associated Clinical Trials

References

May 26, 2009·JACC. Cardiovascular Interventions·Azeem Latib, Antonio Colombo
Feb 26, 2011·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Issam D Moussa
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May 7, 2013·Journal of the American College of Cardiology·Michael MaengUNKNOWN Nordic-Baltic Percutaneous Coronary Intervention Study Group
May 2, 2015·Current Cardiology Reports·Joo Myung LeeHyo-Soo Kim

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Citations

Jun 11, 2016·European Heart Journal·Antonio Colombo, Richard J Jabbour
Nov 21, 2017·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Calin HomorodeanAndrejs Erglis
Dec 8, 2017·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Yu ZhouXiaohui Zhao
Feb 27, 2020·Expert Review of Medical Devices·Anne CornelissenAloke V Finn
Jul 31, 2020·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Woo Jin JangHyeon-Cheol Gwon
Sep 21, 2017·Heart·Raffaele PiccoloStephan Windecker
Apr 7, 2020·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Poay Huan LohAdrian Low
Sep 1, 2015·JACC. Cardiovascular Interventions·Aaron V Kaplan
Jul 31, 2021·The American Journal of Cardiology·Fabrizio D'AscenzoGaetano Maria De Ferrari
Aug 6, 2021·Circulation Journal : Official Journal of the Japanese Circulation Society·Koya OkabeKazushige Kadota

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