PMID: 9191073Jun 1, 1997Paper

Differential proopiomelanocortin gene expression in the medial basal hypothalamus of rats during pregnancy and lactation

Brain Research. Molecular Brain Research
P E MannR S Bridges

Abstract

Hypothalamic proopiomelanocortin (POMC) gene expression was determined using in situ hybridization histochemistry (ISHH) during pregnancy and lactation in rats with and without prior reproduction experience. POMC mRNA levels in the arcuate nucleus were compared between primigravid (first pregnancy) and multigravid (second pregnancy) and primiparous and multiparous lactating rats, and between these groups and age-matched, regularly cycling, nulliparous females in diestrus. Hybridizations were performed using a digoxigenin-labeled riboprobe complementary to 837 bp of the POMC gene. The number of cells expressing POMC mRNA in the arcuate nucleus decreased in primiparous rats on day 12 of lactation when compared with the number of POMC cells in the arcuate nucleus of nulliparous rats in diestrus. In addition, the number of cells expressing POMC mRNA in multigravid animals was significantly less than in the primigravid group on days 7 and 21 of pregnancy, and on day 12 of lactation in primiparous animals. Repeated reproductive experience affected the number of POMC mRNA positive cells; there were fewer cells expressing POMC mRNA in the multigravid females on day 7 of pregnancy and an increase in the number of POMC cells in the multi...Continue Reading

References

Jul 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·R E MainsN Ling
Mar 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·A S LiottaD T Krieger
Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·F BloomR Guillemin
Aug 1, 1991·Endocrinology·C A Sagrillo, J L Voogt
Jan 22, 1990·Brain Research·A R Gintzler, M C Bohan
Sep 1, 1989·Pharmacology, Biochemistry, and Behavior·P E MannR S Bridges
Jan 1, 1989·Progress in Neurobiology·N Ben-JonathanJ F Hyde
Jan 29, 1987·The New England Journal of Medicine·V C MuseyJ R Preedy
May 1, 1985·The Journal of Endocrinology·F PetragliaA R Genazzani
Sep 1, 1988·Biology of Reproduction·C H Kinsley, R S Bridges
Jul 1, 1986·American Journal of Obstetrics and Gynecology·M P VleugelsR de Graaf
Aug 12, 1982·Brain Research·S L WardlawA G Frantz
Oct 16, 1983·Brain Research·D G Schwartzberg, P K Nakane

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Citations

Jun 15, 2005·Brain Research. Molecular Brain Research·Stephen C GammieAnne M Bronikowski
Aug 14, 1999·Brain Research. Developmental Brain Research·P E MannR S Bridges
Dec 5, 2013·Journal of Molecular Endocrinology·Yoshihiro SuzukiNoboru Murakami
Jun 9, 2007·Physiology & Behavior·David R GrattanRachael A Augustine
May 15, 2007·Physiology & Behavior·Barbara Woodside
Sep 25, 2012·Frontiers in Neuroendocrinology·Barbara WoodsideAlfonso Abizaid
Nov 3, 2007·Endocrinology·Colin T Phillips, Richard D Palmiter
Dec 23, 2016·TheScientificWorldJournal·Claudia Regina Capriglioni CancianSabrina Grassiolli
Dec 3, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jian-Guo CuiJohn R Speakman
Mar 13, 2021·Journal of Neuroendocrinology·Sharon R Ladyman, Virginia L Brooks

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