Differential properties between TRK-820 and U-50,488H on the discriminative stimulus effects in rats

Life Sciences
Tomohisa MoriTsutomu Suzuki

Abstract

It has been demonstrated that the newly synthesized kappa-opioid receptor agonist TRK-820, which has a unique structure that is different from those of other prototypical kappa-opioid receptor agonists such as U-50,488H, exert some behavioral effects that differ from those induced by U-50,488H. Therefore, the present study was designed to examine the possible difference between the discriminative stimulus effects of TRK-820 and U-50,488H in rats. Substitution tests with several kappa-opioid receptor agonists were initiated in rats trained to discriminate between TRK-820 (40 microg/kg) or U-50,488H (3.0 mg/kg) and saline. In the cross-substitution tests, U-50,488H substituted for the discriminative stimulus effects of TRK-820, whereas TRK-820 did not substitute completely for those of U-50,488H, indicating that the discriminative stimulus effects of TRK-820 and U-50,488H were somewhat different. In the substitution tests, E-2078, but not R-84760, substituted for the discriminative stimulus effects of both TRK-820 and U-50,488H. KT-90, CI-977 and ICI-199441 each substituted for the discriminative stimulus effects of U-50,488H, but not to those of TRK-820. These results imply that these kappa-opioid receptor agonists possess U-50,...Continue Reading

References

Jun 9, 1977·Nature·J A LordH W Kosterlitz
Apr 1, 1992·Japanese Journal of Pharmacology·T SuzukiH Nagase
Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R S ZukinA Tempel
Oct 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·C Chavkin, A Goldstein
Nov 7, 1980·European Journal of Pharmacology·J J Teal, S G Holtzman
Jun 1, 1995·Pharmacology, Biochemistry, and Behavior·J BroadbentS I Dworkin
Mar 21, 1998·Chemical & Pharmaceutical Bulletin·H NagaseT Endo
Feb 3, 1999·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·P BroquaS G Dahl
Jan 29, 2000·European Journal of Pharmacology·T EndohH Nagase

❮ Previous
Next ❯

Citations

May 25, 2006·Behavioral Neuroscience·Michael E NizhnikovNorman E Spear
Dec 16, 2005·The AAPS Journal·Thomas E PrisinzanoWayne W Harding
Apr 21, 2009·European Journal of Pharmacology·Satoru YoshikawaHiroshi Ichinose
Jul 26, 2005·Peptides·Richard J Bodnar, Gad E Klein
Jul 12, 2013·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Kazumi YoshizawaTsutomu Suzuki

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.