Differential properties of human stromal cells from bone marrow, adipose, liver and cardiac tissues

Cytotherapy
Joshua KellnerIan K McNiece

Abstract

Mesenchymal stromal cells (MSCs), derived from several tissues including bone marrow and adipose tissue, are being evaluated in clinical trials for a range of diseases. Virtually all tissues of the body contain stromal cells, yet it is unknown whether these sources are similar in phenotype and function. We have isolated stromal cells from several human tissues including bone marrow (BM-MSCs), heart (heart stroma, HS), adipose (adipose stroma, AS) and liver (liver stroma, LS) and compared the morphology, phenotype and functional properties of these stromal cell populations. The cellular phenotype of each population was identical, namely, CD105+, CD73+, CD90+, CD34- and CD45-. In addition, morphology and differentiation potential were comparable. Co-culture studies revealed similar supportive potential of BM-MSCs, AS and LS with hematopoietic cells or tumor cells. In contrast, significant inhibition of proliferation of both cells types was obtained with HS, with significant loss of viability with tumor cells, demonstrating a unique functional property of HS with regard to tumor cell proliferation. Although stromal cells from different tissues have similar morphology and phenotype, their functional properties vary, requiring criti...Continue Reading

References

Jan 1, 1982·Journal of Cellular Physiology. Supplement·T M Dexter
Apr 2, 1999·Science·M F PittengerD R Marshak
Aug 3, 2002·Nature Reviews. Cancer·Ann F ChambersIan C MacDonald
Nov 29, 2002·Calcified Tissue International·C RosadaM Kassem
Dec 12, 2002·Molecular Biology of the Cell·Patricia A ZukMarc H Hedrick
Oct 24, 2003·Nature·L M CalviD T Scadden
Dec 8, 2004·Stem Cells·Pieternella S In 't AnkerHumphrey H H Kanhai
Jan 11, 2007·American Journal of Physiology. Renal Physiology·Florian TögelChristof Westenfelder
Jan 30, 2007·Biochemical and Biophysical Research Communications·Yoshitaka IsoDarwin J Prockop
Jun 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Luis A OrtizDonald G Phinney
May 13, 2008·Lancet·Katarina Le BlancUNKNOWN Developmental Committee of the European Group for Blood and Marrow Transplantation
Mar 26, 2010·Trends in Molecular Medicine·James Ankrum, Jeffrey M Karp
Sep 14, 2010·Cardiovascular Research·Alessandra RossiniMaurizio C Capogrossi
Mar 23, 2012·JAMA : the Journal of the American Medical Association·Jianming TanCamillo Ricordi
Jul 4, 2013·Stem Cells and Development·Mariano Di TrapaniMauro Krampera
Aug 21, 2014·BioMed Research International·Dar-Ren ChenWei-Lan Yeh

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Citations

Oct 22, 2016·Advanced Pharmaceutical Bulletin·Davod Pashoutan SarvarParvin Akbarzadehlaleh
May 25, 2016·Journal of Gastroenterology and Hepatology·Wei-Lun TsaiShih-Chieh Hung
Feb 6, 2018·Advanced Pharmaceutical Bulletin·Hamze TimariSara Aqmasheh
Sep 25, 2019·Cells·Irina V KholodenkoKonstantin N Yarygin
May 14, 2021·Frontiers in Cell and Developmental Biology·Stefania BrunoGiovanni Camussi

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