Differential protective effects of Radix astragali, herbal medicine, on immobilization-induced atrophy of slow-twitch and fast-twitch muscles.

Biomedical Research
Risa NozakiShuichi Machida

Abstract

Radix astragali is a popular traditional herbal medicine that provides significant protection against tissue injury in various models of oxidative stress-related diseases. In this study, we aimed to investigate whether administration of Radix astragali prevented atrophy in both slow- and fast-twitch muscles following cast immobilization. Twenty-seven 12-week-old male F344 rats were divided into three experimental groups: control (CON), immobilized (IM), and immobilized with Radix astragali administration (IM+AR). Rats in the IM and IM+AR groups were subjected to immobilization of both lower extremities using casting-tape for 14 days. Rats in the IM+AR group were orally administered a decoction of Radix astragali daily for 21 days beginning 7 days before cast immobilization. As expected, rats in the IM group showed significant decreases (P < 0.05) in soleus and plantaris muscle-to-body weight ratios by 74.3% and 70.5%, respectively, compared with those in the CON group. Administration of Radix astragali significantly reversed (+35.5%) the weight reduction observed in soleus muscle, but not in the plantaris muscle, compared with that in the IM group. Furthermore, administration of Radix astragali inhibited MuRF1 mRNA expression o...Continue Reading

References

Jan 7, 2004·Medicine and Science in Sports and Exercise·Shuichi Machida, Frank W Booth
Jan 29, 2005·Acta Physiologica Scandinavica·S Machida, F W Booth
Jul 28, 2005·American Journal of Physiology. Endocrinology and Metabolism·Brian J KrawiecCharles H Lang
Oct 25, 2007·Aviation, Space, and Environmental Medicine·Haixiang ZhangXiaoli Fan
Mar 21, 2008·The EMBO Journal·Julie Lagirand-CantaloubeSerge A Leibovitch
Jul 19, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Cécile PolgeDaniel Taillandier
Jun 27, 2013·The International Journal of Biochemistry & Cell Biology·Sue C Bodine
Feb 1, 2015·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Yuki KishidaKeisuke Hagihara
Apr 28, 2016·The Journal of Physiological Sciences : JPS·Toshinori YoshiharaTakao Sugiura

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