Differential Protein Expression Profiles in Glaucomatous Trabecular Meshwork: An Evaluation Study on a Small Primary Open Angle Glaucoma Population

Advances in Therapy
Alessandra MiceraFrancesco Oddone

Abstract

Primary open angle glaucoma (POAG) is a progressive optic neuropathy characterized by impaired aqueous outflow and extensive remodeling in the trabecular meshwork (TM). The aim of this study was to characterize and compare the expression patterns of selected proteins belonging to the tissue remodeling, inflammation and growth factor pathways in ex vivo glaucomatous and post-mortem TMs using protein-array analysis. TM specimens were collected from 63 white subjects, including 40 patients with glaucoma and 23 controls. Forty POAG TMs were collected at the time of surgery and 23 post-mortem specimens were from non-glaucomatous donor sclerocorneal tissues. Protein profiles were evaluated using a chip-based array consisting of 60 literature-selected antibodies. A different expression of some factors was observed in POAG TMs with respect to post-mortem specimens, either in abundance (interleukin [IL]10, IL6, IL5, IL7, IL12, IL3, macrophage inflammatory protein [MIP]1δ/α, vascular endothelial growth factor [VEGF], transforming growth factor beta 1 [TGFβ1], soluble tumor necrosis factor receptor I [sTNFRI]) or in scarcity (IL16, IL18, intercellular adhesion molecule 3 [ICAM3], matrix metalloproteinase-7 [MMP7], tissue inhibitor of meta...Continue Reading

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Citations

Nov 1, 2018·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Andrea CacciamaniAlessandra Micera
Nov 27, 2018·Translational Neuroscience·Qing YangLin Luo
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Dec 14, 2019·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Tasneem P SharmaColleen M McDowell
Mar 5, 2020·Cell Death & Disease·Yuki NakanoYoshiaki Kiuchi
Oct 4, 2020·Journal of Clinical Medicine·Stefania VernazzaSergio Claudio Saccà
Jun 28, 2019·Current Medicinal Chemistry·María Garranzo-AsensioAna Guzman-Aranguez
Feb 19, 2021·Journal of Cellular and Molecular Medicine·Aihua LiuLijie Dong
Oct 20, 2020·Progress in Retinal and Eye Research·Christophe BaudouinElisabeth M Messmer
Aug 28, 2021·Biology·Andrés Fernández-Vega CuetoHéctor González-Iglesias

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