Differential proteomic profiling of primary and recurrent chordomas

Oncology Reports
Su ChenJianru Xiao

Abstract

Chordomas are locally destructive tumors with high rates of recurrence and a poor prognosis. The mechanisms involved in chordoma recurrence remain largely unknown. In the present study, we examined the proteomic profile of a chordoma primary tumor (CSO) and a recurrent tumor (CSR) through mass spectrum in a chordoma patient who underwent surgery. Bioinformatic analysis of the profile showed that 359 proteins had a significant expression difference and 21 pathways had a striking alteration between the CSO and the CSR. The CSR showed a significant increase in carbohydrate metabolism. Immunohistochemistry (IHC) confirmed that the cancer stem cell marker activated leukocyte cell adhesion molecule (ALCAM or CD166) expression level was higher in the recurrent than that in the primary tumor. The present study analyzed the proteomic profile change between CSO and CSR and identified a new biomarker ALCAM in recurrent chordomas. This finding sheds light on unraveling the pathophysiology of chordoma recurrence and on exploring more effective prognostic biomarkers and targeted therapies against this devastating disease.

References

Jun 23, 2006·Breast Cancer Research and Treatment·Diane PalmieriPatricia S Steeg
Oct 28, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Wentao LiuYanzhen Lin
Jan 4, 2008·Breast Cancer Research and Treatment·M IhnenK Milde-Langosch
Feb 19, 2008·Translational Research : the Journal of Laboratory and Clinical Medicine·Solomon F Ofori-Acquah, Judy A King
Mar 19, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Delia MezzanzanicaSilvana Canevari
May 17, 2008·Cancer Research·Jeroen W J van KilsdonkGuido W M Swart
Dec 20, 2008·International Journal of Radiation Oncology, Biology, Physics·Thomas F DeLaneyFrancis J Hornicek
Feb 21, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kimberly Laskie OstrowDavid Sidransky
Apr 21, 2009·Nature Methods·Jacek R WiśniewskiMatthias Mann
Feb 26, 2010·Nutrition & Metabolism·Thomas N Seyfried, Laura M Shelton
Aug 7, 2010·Methods in Molecular Biology·Ronald SimonGuido Sauter
Aug 20, 2010·Journal of Surgical Oncology·Hua ZhouZhong-jun Liu
May 7, 2011·Nucleic Acids Research·Takuji YamadaPeer Bork
Aug 6, 2011·The Journal of Surgical Research·Michael TachezyMaximilian Bockhorn
Aug 23, 2011·International Journal of Cancer. Journal International Du Cancer·Michael TachezyMaximilian Bockhorn
Oct 28, 2011·Nutrition & Metabolism·Rainer J Klement, Ulrike Kämmerer
Apr 10, 2012·The Journal of Surgical Research·Michael TachezyMaximilian Bockhorn
Jun 30, 2012·PloS One·Michael TachezyMaximilian Bockhorn

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