Differential-pulse polarography (DPP) determination of betamethasone valerate in dosage form

Analytical and Bioanalytical Chemistry
J-E Belgaied

Abstract

The electrochemical reduction of betamethasone valerate (BV) in a pharmaceutical formulation containing neomycin has been carried out in Britton-Robinson buffer (BRB) (0.04 mol L(-1)) by differential-pulse polarography (DPP). BV exhibits a well-defined irreversible reduction peak at -1.03 V/ref. The influence of pH on the reduction of BV was studied in Britton-Robinson buffer (pH range 1.7-10). A method for the analysis of BV in BRB (0.04 mol L(-1)), which allows quantification over the range 3.9x10(-6)-1.1x10(-4) mol L(-1), was proposed and successfully applied to the determination of BV in tablets with mean recovery and relative standard deviation of 100.81% and 0.45%, respectively.

Citations

Jun 3, 2004·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Sándor Görög
May 24, 2005·Journal of Pharmaceutical and Biomedical Analysis·I TapsobaK Boujlel
Jan 24, 2015·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Hayam Mahmoud LotfyAhmed Samir

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