PMID: 6169402Nov 2, 1981Paper

Differential pulse voltammetry in brain tissue. I. Detection of 5-hydroxyindoles in the rat striatum

Brain Research
R CespuglioM Jouvet

Abstract

In vitro, differential pulse voltammetry combined with electrochemically treated carbon fiber electrodes enabled detection, in different solution of 5-hydroxyindole compounds, of an oxidation peak 3 at +300 mV. In vivo, a striatal peak 3 was also recorded at this potential. Electrolytic or 5,7-dihydroxytryptamine lesions interrupting the medial forebrain bundle (MFB) were followed by a decrease of 65% and 64% in peak height, but not elimination of the peak. Biochemical determinations were significantly correlated to the peak 3 measurements. The existence of peak 3 as well as hydroxyindole compounds in blood suggested a blood contamination under the experimental conditions employed. This possibility is confirmed both by the complete disappearance of striatal peak 3 in animals with the MFB lesioned and surgically prepared a week before recordings, and by biochemical measurements in parachlorophenylalanine-treated or perfused (phosphate-buffered saline solution) animals.

References

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Citations

Oct 1, 1985·Brain Research·J A Stamford
Jul 1, 1993·Journal of Neuroscience Methods·K T KawagoeR M Wightman
Jul 17, 1999·Neuroscience·S BurletR Cespuglio
Jun 9, 2016·Biosensors & Bioelectronics·I Mitch TaylorXinyan Tracy Cui
Jan 1, 1986·Annals of the New York Academy of Sciences·P J KnottJ G Young
Jan 21, 2017·Analytical Chemistry·Tongfang XiaoLanqun Mao

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