Oct 1, 1977

Differential reactivity of the gravid uterine vasculatures: effects of norepinephrine

American Journal of Obstetrics and Gynecology
S G AndersonF C Greiss

Abstract

Norepinephrine dose-conductance-response relationships were determined for the placental and nonplacental vasculatures of ewes between 95 and 130 days of gestation with the use of radioactive-labeled microspheres injected under flow meter guidance. The regression line for the placental circulation differed significantly from that for the nonplacental circulation (P less than 0.01). The decrease in nonplacental conductance was 30 to 45% of control greater than the decrease in placental conductance. These responses are consistent with the hypothesis that the site of placental vascular resistance is in vessels of larger caliber than those which are usually the primary site of resistance to blood flow.

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Mentioned in this Paper

Vascular Resistance
Uterus
Diastolic Blood Pressure
Placenta
Dall Sheep
Regional Blood Flow
Pregnancy, Animal
Norepinephrine, (+, -)-Isomer
Blood Flow
Pulmonary Vascular Resistance

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