Differential recognition of members of the carcinoembryonic antigen family by Opa variants of Neisseria gonorrhoeae.

Infection and Immunity
M P BosR J Belland

Abstract

Opacity (Opa) protein variation in Neisseria gonorrhoeae is implicated in the pathogenesis of gonorrhea, possibly by mediating adherence and entry of the bacteria into human tissues. One particular Opa protein mediates adherence to epithelial cells through cell surface proteoglycans. Recently, two other eukaryotic cell receptors for Opa proteins have been reported. These receptors are members of a subgroup of the carcinoembryonic (CEA) gene family that express CD66 antigens. CEA family members vary in their distribution in human tissues. In order to understand whether interactions between Opa and CEA-like molecules play any role in pathogenesis, we must investigate which CEA family members are able to serve as Opa receptors and which Opa proteins recognize CEA-like molecules. We therefore studied HeLa cells that were stably transfected with five different members of the CEA family, i.e., CEA, CEA gene family member 1a (CGM1a), CGM6, nonspecific cross-reacting antigen (NCA), and biliary glycoprotein a (BGPa). We infected these transfectants with all possible 11 Opa variants of gonococcal strain MS11 and determined the numbers of bacteria that were bound and internalized. To account for proteoglycan-mediated adherence, infection ...Continue Reading

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Citations

Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·M P BosR J Belland
Sep 9, 1998·The Journal of Experimental Medicine·J P van PuttenJ Carlson
Feb 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·K M SkubitzA P Skubitz
Oct 14, 2000·Annual Review of Cell and Developmental Biology·A J Merz, M So
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Apr 16, 2005·Clinical Microbiology Reviews·Alain L Servin
May 26, 2006·Nature Reviews. Immunology·Scott D Gray-Owen, Richard S Blumberg
Dec 17, 2008·Journal of Translational Medicine·Keith M Skubitz, Amy P N Skubitz
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Nov 18, 2003·Molecular Microbiology·Marien I de JongePeter van der Ley
Sep 15, 2004·FEMS Immunology and Medical Microbiology·Milica PantelicTie Chen
Jan 6, 2011·FEMS Microbiology Reviews·Manish SadaranganiScott D Gray-Owen
Oct 6, 2020·Frontiers in Cellular and Infection Microbiology·Tao YangThomas Rudel
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Oct 24, 2002·European Journal of Biochemistry·Marien I de JongePeter van der Ley
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