PMID: 3771317Nov 1, 1986Paper

Differential reduction by caffeine of adriamycin induced cell killing and cell cycle delays in Chinese hamster V79 cells

International Journal of Radiation Oncology, Biology, Physics
G IliakisA Yen

Abstract

Exponentially growing Chinese-hamster V79-cells were treated with various doses of adriamycin (ADR) for 1 hr in the presence or absence of 2 mM caffeine and were subsequently incubated for 24 hr in fresh medium with or without caffeine (2 mM) before plating to assay for survival. The results indicated a reduction in killing when caffeine was present during treatment with ADR (e.g., reduction in killing from 0.03 to 0.3 after exposure to 0.5 microgram/ml ADR). This reduction in killing was even more pronounced after a 24 hr treatment with ADR in the presence of caffeine (e.g., reduction from 0.005 to 0.5 after exposure to 0.08 microgram/ml ADR). Incubation with caffeine after ADR treatment (1 hr) caused only a comparably small increase in cell survival. Presence of caffeine either simultaneously or after treatment with ADR caused a reduction of the inhibition of growth and mean-cell-volume increase, and a reduction of the accumulation of cells in G2-phase. Qualitatively similar results were also obtained after continuous treatment with ADR in the presence or absence of caffeine. Reduction in growth inhibition and accumulation of cells in G2-phase was observed under conditions only slightly affecting cell survival, thus suggestin...Continue Reading

References

May 1, 1978·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·T D GriffithsD B Dahle
Aug 1, 1979·International Journal of Radiation Oncology, Biology, Physics·R M SutherlandD Vanantwerp
Jun 1, 1973·Biochemical Medicine·H S Schwartz
May 1, 1971·Mutation Research·I G Walker, B D Reid
Jan 1, 1969·Cancer·J Whang-PengS Perry
Dec 1, 1982·Cellular Immunology·A Yen, D G Fairchild
Jan 15, 1981·Biochemical and Biophysical Research Communications·T R KrughD E Graves
Jan 1, 1946·The Biochemical Journal·H Weil-Malherbe

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Citations

Nov 11, 2011·Journal of Fluorescence·Soma BanerjeeSamir Kumar Pal
Jan 1, 1995·Toxicology Letters·Y SadzukaY Takino
Mar 1, 1993·Japanese Journal of Cancer Research : Gann·Y SadzukaY Takino
Jun 1, 1995·Japanese Journal of Cancer Research : Gann·Y SadzukaS Hirota
Apr 7, 2018·Critical Reviews in Food Science and Nutrition·João MonteiroBranca M Silva
Jan 1, 1990·Cell and Tissue Kinetics·J E KunickaZ Darzynkiewicz
Apr 21, 1998·Japanese Journal of Cancer Research : Gann·Y SadzukaK Miyamoto
May 1, 1991·Cell Proliferation·F TraganosZ Darzynkiewicz
Dec 14, 2001·Journal of Medicinal Chemistry·M B LylesH R Rawls

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