Differential regional development of tolerance to increase in dopamine turnover upon repeated neuroleptic administration

European Journal of Pharmacology
B Scatton

Abstract

Repeated treatment with haloperidol and sulpiride induced tolerance to the increases in homovanillic and dihydroxyphenyl acetic acids in the striatum, nucleus accumbens, tuberculum olfactorium and frontal cortex of the rat. The threshold dose inducing this effect appeared to be lower in the striatum than in the limbic regions. Similar results were found in the frontal cortex by measuring dopamine utilization. Moreover, tolerance developed earlier in the striatum than in the limbic areas. The possible reasons are discussed for the differential development of tolerance in the various DA areas investigated.

References

Sep 1, 1976·European Journal of Pharmacology·M B Bowers, A Rozitis
Jul 30, 1975·Naunyn-Schmiedeberg's Archives of Pharmacology·B ScattonL Julou
Jan 1, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·P LaduronJ Leysen
May 1, 1977·Neuropharmacology·G Bartholini, H Stadler
Jul 1, 1976·European Journal of Pharmacology·P C Waldmeier, L Maître
Aug 1, 1976·Neuropharmacology·R Miller
Apr 1, 1975·European Journal of Pharmacology·G G Yarbrough
Jan 11, 1974·Psychopharmacologia·I Moller NielsenM Nymark

Citations

Aug 6, 2005·Journal of Neural Transmission·Anders FredrikssonTrevor Archer
Aug 19, 1983·European Journal of Pharmacology·M J BannonR H Roth
May 7, 1987·European Journal of Pharmacology·J M FinlayH C Fibiger
Jul 1, 1987·Neuropharmacology·K E MooreK J Lookingland
Jan 1, 1988·Physiology & Behavior·A RayR M Sullivan
Feb 1, 1987·Pharmacology, Biochemistry, and Behavior·J H GordonW C Koller
Jan 1, 1990·Progress in Neuro-psychopharmacology & Biological Psychiatry·L HernandezB G Hoebel
Jan 1, 1994·Progress in Neuro-psychopharmacology & Biological Psychiatry·I AndiaR Davila
Jan 1, 1983·Progress in Neurobiology·R H FishmanH L Klawans
Oct 31, 1998·Brain Research. Molecular Brain Research·T NakaharaH Uchimura
Dec 15, 2000·Progress in Neurobiology·T M Tzschentke
Feb 1, 1980·Psychological Medicine·C D Marsden, P Jenner
Aug 16, 1994·Proceedings of the National Academy of Sciences of the United States of America·J H Meador-WoodruffS J Watson
Jan 1, 1990·Annals of the New York Academy of Sciences·M E Wolf, R H Roth
Jul 6, 2000·The Australian and New Zealand Journal of Psychiatry·P S Sachdev
Aug 13, 2004·The European Journal of Neuroscience·Kerstin HåkanssonGilberto Fisone
Jan 1, 1988·Annals of the New York Academy of Sciences·E Widerlöv
Jan 28, 1982·Brain Research·B ScattonG Bartholini
Apr 15, 1988·Biological Psychiatry·G R StonerD W Hommer
Aug 6, 1984·Brain Research·M H BassantB Scatton
Jan 1, 1986·Annals of the New York Academy of Sciences·R F Lane, C D Blaha
Jan 1, 1988·Annals of the New York Academy of Sciences·C D KiltsR B Mailman
Jul 1, 1985·Journal of Neurochemistry·C MissaleI Hanbauer
Jan 1, 1984·Annals of the New York Academy of Sciences·R H Roth
Jan 1, 1997·Journal of Psychopharmacology·M B Knable, D R Weinberger
Jan 1, 1987·Journal of Psychopharmacology·S D Iversen
Jul 1, 1997·Clinical Pediatrics·F X Castellanos
Jan 1, 1981·Acta Psychiatrica Scandinavica. Supplementum·K E Moore
Sep 1, 1983·The British Journal of Psychiatry : the Journal of Mental Science·C M Bonthala, A West
Aug 1, 1982·The Journal of Pharmacy and Pharmacology·J A Van Der KrogtR D Belfroid
Aug 19, 2007·Neurochemical Research·Trevor Archer, Anders Fredriksson

Related Concepts

Metazoa
Brain
Intropin
Drug Tolerance
Haldol
Homovanillic Acid
Sulpor
3,4-Dihydroxyphenylacetic Acid, Monosodium Salt
Rats, Laboratory

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.