Differential regional development of tolerance to increase in dopamine turnover upon repeated neuroleptic administration

European Journal of Pharmacology
B Scatton


Repeated treatment with haloperidol and sulpiride induced tolerance to the increases in homovanillic and dihydroxyphenyl acetic acids in the striatum, nucleus accumbens, tuberculum olfactorium and frontal cortex of the rat. The threshold dose inducing this effect appeared to be lower in the striatum than in the limbic regions. Similar results were found in the frontal cortex by measuring dopamine utilization. Moreover, tolerance developed earlier in the striatum than in the limbic areas. The possible reasons are discussed for the differential development of tolerance in the various DA areas investigated.


Sep 1, 1976·European Journal of Pharmacology·M B Bowers, A Rozitis
Jul 30, 1975·Naunyn-Schmiedeberg's Archives of Pharmacology·B ScattonL Julou
Jan 1, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·P LaduronJ Leysen
May 1, 1977·Neuropharmacology·G Bartholini, H Stadler
Jul 1, 1976·European Journal of Pharmacology·P C Waldmeier, L Maître
Aug 1, 1976·Neuropharmacology·R Miller
Apr 1, 1975·European Journal of Pharmacology·G G Yarbrough
Jan 11, 1974·Psychopharmacologia·I Moller NielsenM Nymark


Aug 6, 2005·Journal of Neural Transmission·Anders FredrikssonTrevor Archer
Aug 19, 1983·European Journal of Pharmacology·M J BannonR H Roth
May 7, 1987·European Journal of Pharmacology·J M FinlayH C Fibiger
Jul 1, 1987·Neuropharmacology·K E MooreK J Lookingland
Jan 1, 1988·Physiology & Behavior·A RayR M Sullivan
Feb 1, 1987·Pharmacology, Biochemistry, and Behavior·J H GordonW C Koller
Jan 1, 1990·Progress in Neuro-psychopharmacology & Biological Psychiatry·L HernandezB G Hoebel
Jan 1, 1994·Progress in Neuro-psychopharmacology & Biological Psychiatry·I AndiaR Davila
Jan 1, 1983·Progress in Neurobiology·R H FishmanH L Klawans
Oct 31, 1998·Brain Research. Molecular Brain Research·T NakaharaH Uchimura
Dec 15, 2000·Progress in Neurobiology·T M Tzschentke
Feb 1, 1980·Psychological Medicine·C D Marsden, P Jenner
Aug 16, 1994·Proceedings of the National Academy of Sciences of the United States of America·J H Meador-WoodruffS J Watson
Jan 1, 1990·Annals of the New York Academy of Sciences·M E Wolf, R H Roth
Jul 6, 2000·The Australian and New Zealand Journal of Psychiatry·P S Sachdev
Aug 13, 2004·The European Journal of Neuroscience·Kerstin HåkanssonGilberto Fisone
Jan 1, 1988·Annals of the New York Academy of Sciences·E Widerlöv
Jan 28, 1982·Brain Research·B ScattonG Bartholini
Apr 15, 1988·Biological Psychiatry·G R StonerD W Hommer
Aug 6, 1984·Brain Research·M H BassantB Scatton
Jan 1, 1986·Annals of the New York Academy of Sciences·R F Lane, C D Blaha
Jan 1, 1988·Annals of the New York Academy of Sciences·C D KiltsR B Mailman
Jul 1, 1985·Journal of Neurochemistry·C MissaleI Hanbauer
Jan 1, 1984·Annals of the New York Academy of Sciences·R H Roth
Jan 1, 1997·Journal of Psychopharmacology·M B Knable, D R Weinberger
Jan 1, 1987·Journal of Psychopharmacology·S D Iversen
Jul 1, 1997·Clinical Pediatrics·F X Castellanos
Jan 1, 1981·Acta Psychiatrica Scandinavica. Supplementum·K E Moore
Sep 1, 1983·The British Journal of Psychiatry : the Journal of Mental Science·C M Bonthala, A West
Aug 1, 1982·The Journal of Pharmacy and Pharmacology·J A Van Der KrogtR D Belfroid
Aug 19, 2007·Neurochemical Research·Trevor Archer, Anders Fredriksson

Related Concepts

Drug Tolerance
Homovanillic Acid
3,4-Dihydroxyphenylacetic Acid, Monosodium Salt
Rats, Laboratory

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