PMID: 7540272Mar 3, 1995Paper

Differential regulation of adenylate cyclase activity in rat ventral and dorsal hippocampus by rat galanin

Neuroscience Letters
A ValknaU Langel

Abstract

Rat galanin inhibits basal as well as forskolin-stimulated adenylate cyclase activity in rat ventral and dorsal hippocampus. The inhibition of adenylate cyclase activity, both basal and forskolin-stimulated, is characterised by IC50 values being 250-fold lower in ventral hippocampus (IC50 = 1.1 nM) compared to the dorsal hippocampus (IC50 = 270 nM). The maximal inhibition of basal and forskolin-stimulated adenylate cyclase activity in both ventral and dorsal hippocampus in the presence of 10 microM rat galanin is 34-45%. The analysis of the binding data obtained with 125I-labelled Tyr26-porcine galanin as a tracer reveals similar binding constants for rat galanin in both ventral and dorsal hippocampus with 4.8-fold higher concentration of galanin receptors in the ventral hippocampus. Putative galanin receptor subtype differences between the ventral and dorsal hippocampus have been noted by Hedlund et al. (Eur. J. Pharmacol., 224 (1992) 203-205). This study yields further confirmation for the existence of different galanin receptor subtypes or for differential coupling of galanin receptors to the adenylate cyclase in the dorsal versus ventral hippohampus.

References

Dec 2, 1992·European Journal of Pharmacology·P B HedlundK Fuxe
Jun 1, 1992·International Journal of Peptide and Protein Research·U LangelT Bartfai
Apr 15, 1989·European Journal of Biochemistry·G FisoneT Bartfai
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·T BartfaiR Corwin
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·E Habert-OrtoliJ F Mayaux
Oct 14, 1994·European Journal of Pharmacology·E HeuilletJ C Blanchard

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Citations

Dec 1, 1995·Cellular and Molecular Neurobiology·K KaskT Bartfai
May 10, 2003·Neurobiology of Learning and Memory·Jefferson W KinneyJacqueline N Crawley
Oct 2, 1998·British Journal of Pharmacology·N NiiroH Kanaide
Feb 3, 1999·Annals of the New York Academy of Sciences·T BranchekM W Walker
May 16, 2002·Proceedings of the National Academy of Sciences of the United States of America·Külliki SaarUlo Langel
Jun 18, 2009·Neurobiology of Learning and Memory·Jefferson W KinneyTamas Bartfai
Apr 3, 1999·Neuropeptides·E Karelson, U Langel
Oct 3, 2002·Neuropeptides·D Wynick, A Bacon
Jan 5, 2002·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·A MazaratiT Bartfai

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