Differential regulation of c-Fos and FosB in the rat brain after amygdala kindling.

Cellular and Molecular Neurobiology
Torsten M MadsenJens D Mikkelsen

Abstract

Members of the inducible transcription factor Fos family, that are part of the AP-1 complex that binds to the corresponding promoter site, are implicated in the regulation of gene transcription after acute and chronic seizures. However, little is known about the temporal expression of the AP-1 transcription factors and if individual proteins composing this complex have distinct roles in development and maintenance of permanent epilepsy. In this study, the AP-1 binding capacity, its content of different Fos proteins, and the anatomical specificity, were analyzed 2 or 18 h after achieving full kindling in rats. The same analysis was performed in fully kindled animal receiving a new stimulus after a 3-week pause to determine the extent of stability of the AP-1 transcription factors. While both c-Fos and FosB were induced in all cortical areas after a single stimulus, only FosB-immunoreactivity remained after 18 h. A single stimulation to kindled animals left undisturbed for 3 weeks induced a long-lasting upregulation of AP-1 binding in the frontal cortex, but not in the hippocampus suggesting a permanent exposure of AP-1 heterocomplexes in the frontal cortex. Supershift assays showed that FosB is the dominant component of the long...Continue Reading

References

Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Mar 1, 1972·Electroencephalography and Clinical Neurophysiology·R J Racine
Nov 1, 1969·Experimental Neurology·G V GoddardC K Leech
Jan 1, 1980·Progress in Neurobiology·J O McNamaraJ G Fitz
Mar 1, 1995·Journal of Neurobiology·T Curran, J I Morgan
Apr 1, 1996·Immunology and Cell Biology·V C Foletta
Jan 1, 1996·Brain Research Bulletin·F J EblingM H Hastings
Sep 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·N HiroiE J Nestler
Jul 24, 1998·Brain Research. Molecular Brain Research·B J ChiassonH A Robertson
Jan 14, 1999·Brain Research Bulletin·J D MikkelsenN Mrosovsky
Oct 9, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jingshan ChenRonald S Duman
Dec 8, 2004·Brain Research. Molecular Brain Research·Colleen A McClungEric J Nestler

❮ Previous
Next ❯

Citations

Aug 30, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Salwa Al-NooriDianne P Figlewicz
Oct 15, 2013·Neuromodulation : Journal of the International Neuromodulation Society·Jose C da SilvaArthur Cukiert
Mar 19, 2015·Cellular and Molecular Neurobiology·Xiaoyan YangXuefeng Wang
Sep 21, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Chandra Sekhar BathinaSteve Mifflin
Jul 2, 2019·Experimental and Therapeutic Medicine·Yan Wang, Zhiping Li

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.