Differential regulation of CHIF mRNA by potassium intake and aldosterone

The American Journal of Physiology
H WaldHaim Garty

Abstract

The channel-inducing factor (CHIF) is an epithelial-specific transmembrane protein, which is induced by aldosterone in distal colon (but not in kidney) and can evoke K+ conductance in Xenopus oocytes. The current study examined the possibility that CHIF participates in maintaining K+ balance by assessing its regulation during variations in K+ intake. In adrenal-intact rats, high-K+ diet stimulated, whereas K+ deficiency downregulated, CHIF mRNA both in kidney and colon. The downregulation of CHIF observed in rats fed a low-K+ diet for different periods of time closely correlated with a decrease in plasma K+ but also with changes in aldosterone levels. To differentiate between the two, modulation of CHIF has been studied in adrenalectomized rats with and without corticosteroid supplementation. These experiments have demonstrated that a low-K+ intake suppresses CHIF mRNA, irrespective of aldosterone level. On the other hand, the upregulation evoked by a high-K+ load is apparent only in adrenal-intact rats. This is despite the fact that infusing rats with aldosterone and corticosterone does not increase the expression of this mRNA in kidney. These findings may suggest a role for CHIF in preserving K+ balance.

Citations

Aug 16, 2000·American Journal of Physiology. Cell Physiology·A G Therien, R Blostein
Feb 22, 2001·American Journal of Physiology. Renal Physiology·H ShiH Garty
May 24, 2003·Annals of the New York Academy of Sciences·Haim GartySteven J D Karlish
Mar 7, 2002·American Journal of Physiology. Renal Physiology·James D Stockand
Aug 13, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Christian K TipsmarkSteffen S Madsen
Jan 5, 2002·Physiological Reviews·Karl Kunzelmann, Marcus Mall
Feb 16, 2006·American Journal of Physiology. Renal Physiology·Qi CaiHeddwen L Brooks
Oct 20, 2006·American Journal of Physiology. Cell Physiology·Elena ArystarkhovaKathleen J Sweadner
Dec 25, 2004·Physiological Reviews·Steven C HebertWenhui Wang
Aug 9, 2002·American Journal of Physiology. Renal Physiology·Roman AizmanHaim Garty
Sep 10, 2002·American Journal of Physiology. Renal Physiology·Haim GartySteven J D Karlish

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