Differential regulation of collagen types I and III expression in cardiac fibroblasts by AGEs through TRB3/MAPK signaling pathway

Cellular and Molecular Life Sciences : CMLS
M TangW Zhang

Abstract

Advanced glycation end products (AGEs) play an important role in collagen deposition in diabetic cardiomyopathy. TRB3, a mammalian homolog of Drosophila tribbles, functions to increase glucose intolerance and regulates cell proliferation. We demonstrated that AGEs induce collagen type I expression but inhibit collagen type III expression, accompanied by increased TRB3 expression. Furthermore, the collagen type I induced byAGEs was down-regulated after inhibition of ERK and p38-MAPK, the collagen type III reduced by AGEs was up-regulated after inhibition of ERK. The expression of collagen types I and III regulated by AGEs through MAPK was partly reversed after treatment with TRB3 siRNA. It suggests that the TRB3/MAPK signaling pathway participates in the regulation of collagen types I and III by AGEs and may provide new therapeutic strategies for diabetic cardiomyopathy.

Citations

Oct 12, 2012·Pflügers Archiv : European journal of physiology·Li-Mei ZhaoXiu-Ling Deng
Oct 12, 2012·Journal of Cardiovascular Translational Research·Katrina Go YamazakiAlexander C Zambon
Dec 10, 2009·American Journal of Physiology. Endocrinology and Metabolism·Jiarong LiuW Timothy Garvey
Jul 28, 2010·American Journal of Physiology. Renal Physiology·Elizabeth MorseRobyn Cunard
May 18, 2011·BMC Cell Biology·Chi-Young WangHung-I Yeh
Dec 7, 2013·Chemico-biological Interactions·Subramanian UmadeviVellaichamy Elangovan
Apr 16, 2010·Canadian Journal of Physiology and Pharmacology·Madhu KhullarPawan K Singal
Oct 6, 2009·Matrix Biology : Journal of the International Society for Matrix Biology·Sihem Sassi-GahaCarol M Artlett
Apr 25, 2009·The FEBS Journal·Yuan-yuan ShangWei Zhang
Jan 30, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Emily L MiedelSusan W Volk
Apr 23, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Werner E G MüllerXiaohong Wang
May 21, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Juan ZhaoRong Lu
Jul 21, 2016·Experimental Gerontology·John T KimJeffrey C Wolchok
Nov 16, 2018·Physiological Reports·Patricia Rouet-BenzinebEvelyne Polidano
Aug 10, 2019·Journal of Cardiovascular Development and Disease·Neil A Turner, Nicola M Blythe
Feb 7, 2020·International Journal of Molecular Sciences·Scott P Levick, Alexander Widiapradja
Feb 1, 2011·Immunopharmacology and Immunotoxicology·Xueping ZhouMianhua Wu
Sep 8, 2011·Journal of Cell Science·Fang HuaZhuowei Hu
Mar 31, 2021·Cardiovascular Research·Qutuba G KarwiGary D Lopaschuk
Aug 1, 2021·Advanced Drug Delivery Reviews·Izabela Tuleta, Nikolaos G Frangogiannis

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