PMID: 8584417Nov 1, 1995Paper

Differential regulation of cytosolic calcium between afferent arteriol ar smooth muscle cells from mouse kidney

Pflügers Archiv : European journal of physiology
H Scholz, A Kurtz

Abstract

Using a combination of whole-cell patch-clamping and calcium microspectrofluorimetry we have examined the calcium regulation and calcium-activated electrical currents in smooth muscle cells along mouse renal afferent arterioles. In cells located at a distance up to 50microm from the glomerular vascular pole, guanosine 5'-[gamma-thio]triphosphate, (GTP[tau -S], 100micromol/l) and angiotensin II (1micromol/l) evoked internal calcium mobilization and oscillations of intracellular calcium concentration. Membrane depolarization up to +30mV did not increase cytosolic free calcium in these cells, which displayed calcium-activated chloride currents. In cells located more distant than 100microm from the glomerular vascular pole, GTP[tau -S] did not increase cytosolic calcium at negative membrane potentials. Depolarization of these cells to 0mV or positive membrane potentials increased intracellular calcium in a dihydropyridine-sensitive manner. These cells responded to angiotensin II with single calcium transients and also displayed calcium-activated chloride currents. These findings suggest that intracellular calcium is differentially regulated between afferent arteriolar smooth muscle cells from mouse kidney: in smooth muscle cells wh...Continue Reading

References

May 1, 1990·Pflügers Archiv : European journal of physiology·A KurtzR Penner
Oct 1, 1990·Physiological Reviews·E HackenthalR Taugner
Jan 1, 1990·Spatial Vision·V A Billock, L E Leguire
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A Kurtz, R Penner
Jan 1, 1984·Contributions to Nephrology·R TaugnerR Nobiling
Jan 1, 1984·Journal of Cardiovascular Pharmacology·C P BührleR Taugner
Aug 1, 1981·Pflügers Archiv : European journal of physiology·O P HamillF J Sigworth
Jun 1, 1983·Japanese Journal of Pharmacology·Y AbeK Yamamoto

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Citations

Apr 28, 2012·Pflügers Archiv : European journal of physiology·Douglas K Atchison, William H Beierwaltes
Jun 27, 2012·Pflügers Archiv : European journal of physiology·Ulla G FriisBoye L Jensen
Mar 22, 2002·Clinical and Experimental Pharmacology & Physiology·Pamela K Carmines, Keiji Fujiwara
Jul 1, 1997·Clinical and Experimental Pharmacology & Physiology·A Kurtz
Oct 1, 1996·British Journal of Pharmacology·K SchrickerA Kurtz
Oct 13, 2010·Annual Review of Physiology·Armin Kurtz
Jul 31, 2004·Acta Physiologica Scandinavica·U G FriisO Skøtt
Jul 31, 2004·Acta Physiologica Scandinavica·F Schweda, A Kurtz
Jul 31, 2004·Acta Physiologica Scandinavica·M SalomonssonN-H Holstein-Rathlou
Nov 3, 2005·American Journal of Physiology. Renal Physiology·Ming-Guo Feng, L Gabriel Navar
Apr 3, 2015·Physiological Reviews·Mattias CarlströmWilliam J Arendshorst
Apr 16, 2010·Physiological Reviews·Hayo CastropCharlotte Wagner
Jan 24, 2018·American Journal of Physiology. Renal Physiology·D SteppanA Kurtz
Oct 12, 2007·Physiology·Frank SchwedaArmin Kurtz
Jul 15, 2000·American Journal of Physiology. Renal Physiology·F SchwedaB K Krämer
Oct 30, 2003·American Journal of Physiology. Renal Physiology·Ming-Guo FengL Gabriel Navar

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