PMID: 8590800Dec 1, 1995Paper

Differential regulation of distinct types of gap junction channels by similar phosphorylating conditions

Molecular Biology of the Cell
B R KwakMarc Chanson

Abstract

Studies on physiological modulation of intercellular communication mediated by protein kinases are often complicated by the fact that cells express multiple gap junction proteins (connexins; Cx). Changes in cell coupling can be masked by simultaneous opposite regulation of the gap junction channel types expressed. We have examined the effects of activators and inhibitors of protein kinase A (PKA), PKC, and PKG on permeability and single channel conductance of gap junction channels composed of Cx45, Cx43, or Cx26 subunits. To allow direct comparison between these Cx, SKHep1 cells, which endogenously express Cx45, were stably transfected with cDNAs coding for Cx43 or Cx26. Under control conditions, the distinct types of gap junction channels could be distinguished on the basis of their permeability and single channel properties. Under various phosphorylating conditions, these channels behaved differently. Whereas agonists/antagonist of PKA did not affect permeability and conductance of all gap junction channels, variable changes were observed under PKC stimulation. Cx45 channels exhibited an additional conductance state, the detection of the smaller conductance states of Cx43 channels was favored, and Cx26 channels were less ofte...Continue Reading

References

Jul 1, 1978·Analytical Biochemistry·D B GlassB E Kemp
Nov 1, 1992·Pflügers Archiv : European journal of physiology·B R Takens-Kwak, H J Jongsma
Feb 1, 1992·Seminars in Cell Biology·M V Bennett, V K Verselis
Sep 3, 1991·Biochimica Et Biophysica Acta·S Y OhA W Murray
Jun 1, 1991·Journal of Molecular and Cellular Cardiology·A F LauD S Crow
Aug 1, 1990·The Journal of Cell Biology·G I FishmanL A Leinwand
Mar 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·D ZhuC C Naus
Mar 1, 1991·Neuron·M V BennettJ C Sáez
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·B EghbaliD C Spray
Jul 1, 1990·The Journal of Membrane Biology·E C BeyerD A Goodenough
Sep 2, 1985·Nature·J Neyton, A Trautmann
Sep 1, 1989·Biophysical Journal·P R Brink, S F Fan
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J C SaezM V Bennett
Jan 5, 1987·FEBS Letters·A TakedaT Shimazu
Nov 11, 1982·Nucleic Acids Research·F G GrosveldR A Flavell
Sep 1, 1995·Pflügers Archiv : European journal of physiology·B R KwakH J Jongsma
Sep 1, 1994·Circulation Research·R D VeenstraP R Brink
Apr 1, 1995·Pflügers Archiv : European journal of physiology·F F BukauskasR Weingart
Apr 1, 1993·Pflügers Archiv : European journal of physiology·F F Bukauskas, R Weingart
Aug 18, 1993·Biochimica Et Biophysica Acta·H H SchmidtU Walter
Sep 27, 1994·Proceedings of the National Academy of Sciences of the United States of America·T JarchauU Walter
Apr 1, 1994·The Journal of Membrane Biology·J G LaingE C Beyer
Nov 1, 1993·The Journal of General Physiology·M ChansonD C Spray

❮ Previous
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Citations

Sep 1, 1996·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R BruzzoneD A Goodenough
Aug 1, 1996·Journal of Bioenergetics and Biomembranes·T W White, R Bruzzone
Feb 15, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·Aida Salameh, Stefan Dhein
Oct 26, 2005·The Journal of Membrane Biology·A NgezahayoH-A Kolb
Jun 29, 2012·The Journal of Membrane Biology·Scott R JohnstoneBrant E Isakson
Jan 4, 2008·Pflügers Archiv : European journal of physiology·G Hawat, G Baroudi
Jul 10, 2013·European Journal of Pharmacology·Ada PopoloAldo Pinto
Apr 7, 2000·Brain Research. Brain Research Reviews·T W White, R Bruzzone
Sep 10, 2002·Peptides·Stefan Dhein
Feb 5, 2003·Biology of the Cell·Véronique Cruciani, Svein Ole Mikalsen
Jul 21, 2007·Visual Neuroscience·W Wade KothmannJohn O'Brien
Aug 3, 1999·European Journal of Biochemistry·H L Cheng, C F Louis
May 15, 1996·European Journal of Biochemistry·R BruzzoneD L Paul
Mar 28, 1998·The European Journal of Neuroscience·J L VelazquezP L Carlen
Oct 22, 2002·American Journal of Physiology. Cell Physiology·G Trevor CottrellJanis M Burt
Nov 15, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Polina S Petkova-KirovaVladimir E Bondarenko
Jan 19, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Anna PfennigerMario Delmar
May 15, 1997·The Journal of Clinical Investigation·J Hu, I A Cotgreave
Jun 22, 1999·The Journal of Clinical Investigation·M ChansonS Suter
Sep 25, 2010·PLoS Computational Biology·Mati GoldbergEshel Ben-Jacob
Jun 3, 2006·Biological Chemistry·Xianrong ZhangYipeng Qi
Jun 24, 2014·Current Opinion in Neurobiology·John O'Brien
Mar 29, 2001·Journal of Molecular and Cellular Cardiology·N BowlingC J Vlahos
May 1, 2009·Seminars in Immunopathology·Sandrine MorelBrenda R Kwak
Nov 3, 2010·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Yun-Hoon ChoungSeung Joo Lee
Sep 14, 2007·Annals of Medicine·Christos E Chadjichristos, Brenda R Kwak
Dec 3, 2014·Journal of Molecular and Cellular Cardiology·Annabel S CampbellGodfrey Smith
Apr 14, 1999·The Journal of Physiology·B R Kwak, H J Jongsma
Mar 13, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·T DesplantezR Weingart
Jun 28, 2011·Progress in Histochemistry and Cytochemistry·R-Marc Pelletier
Aug 14, 2010·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Aida SalamehIngo Daehnert
Feb 25, 2009·Journal of Structural Biology·Oliver GassmannClaudia Steinem
Feb 13, 2009·Experimental Cell Research·Tanja AuthKlaus Willecke
Feb 16, 2007·Journal of Cellular Physiology·Damian C GenetosHenry J Donahue

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