Differential regulation of Fas-mediated apoptosis in both thyrocyte and lymphocyte cellular compartments correlates with opposite phenotypic manifestations of autoimmune thyroid disease

Thyroid : Official Journal of the American Thyroid Association
C GiordanoA Galluzzo

Abstract

Several mechanisms are probably involved in determining the evolution of autoimmune thyroid disease (AITD) towards either hypothyroidism and the clinical syndrome known as Hashimoto's thyroiditis (HT) or toward hyperthyroidism and the symptoms of Graves' disease (GD). To gain further insight into such mechanisms we performed an exhaustive comparative analysis of the expression of key molecules regulating cell death (Fas, Fas ligand [FasL], Bcl-2) and apoptosis in both thyrocytes and thyroid infiltrating lymphocytes (TILs) from patients with either GD or HT. GD thyrocytes expressed less Fas/FasL than HT thyrocytes, whereas GD TILs had higher levels of Fas/FasL than HT TILs. GD thyrocytes expressed increased levels of the antiapoptotic molecule Bcl-2 compared to the low levels detected in HT thyrocytes. The opposite pattern was observed in GD (low Bcl-2) and HT (high Bcl-2) TILs. The patterns of apoptosis observed were consistent with the regulation of Fas, FasL, and Bcl-2 described above. Our findings suggest that in GD thyroid the regulation of Fas/FasL/Bcl2 favors apoptosis of infiltrating lymphocytes, possibly limiting their autoreactive potential and impairing their ability to mediate tissue damage. Moreover, the reduced lev...Continue Reading

References

Nov 1, 1989·Endocrine Reviews·L J DeGroot, J Quintans
Nov 17, 1995·Science·T S GriffithT A Ferguson
Mar 10, 1995·Science·S Nagata, P Golstein
Oct 19, 1995·Nature·D BellgrauR C Duke
May 1, 1995·The Journal of Allergy and Clinical Immunology·M BagnascoG W Canonica
Feb 14, 1997·Science·N Williams
Apr 1, 1997·Nature Medicine·L E French, J Tschopp
Sep 18, 1997·Immunology Today·B S PrabhakarG S Seetharamaiah
Sep 12, 1998·Science·J M Adams, S Cory
Apr 14, 1999·Cell Death and Differentiation·S Ohsako, K B Elkon
May 20, 1999·Journal of Autoimmunity·S M Dilts, K J Lafferty
Feb 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·F BatteuxG Chiocchia
Mar 14, 2000·Cell Death and Differentiation·J R Baker, J D Bretz
Jun 17, 2000·Cell Death and Differentiation·I HerrK M Debatin
Aug 25, 2000·Thyroid : Official Journal of the American Thyroid Association·T F Davies
Aug 25, 2000·Thyroid : Official Journal of the American Thyroid Association·N MitsiadesD A Koutras

❮ Previous
Next ❯

Citations

Jul 12, 2005·The Journal of Membrane Biology·M Y Kochukov, A K Ritchie
Mar 22, 2012·Immunologic Research·Syed A MorshedTerry F Davies
Jun 20, 2002·Journal of Immunological Methods·R MirakianL J Hammond
Sep 23, 2003·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Yongzhong WeiHelen Braley-Mullen
Jan 30, 2003·Acta histochemica·Pavol JanegaPavel Babál
Feb 13, 2002·Thyroid : Official Journal of the American Thyroid Association·Franco Lumachi, Stefano Basso
Dec 14, 2004·Thyroid : Official Journal of the American Thyroid Association·Yukiyo NakamuraYoshinori Iwatani
Sep 29, 2005·Thyroid : Official Journal of the American Thyroid Association·S KargerD Führer
Mar 15, 2005·Journal of Autoimmune Diseases·Dimitry A Chistiakov
Jan 11, 2014·Langenbeck's Archives of Surgery·Aleksander KonturekWojciech Wierzchowski
Mar 31, 2004·Clinical Endocrinology·Stelios Fountoulakis, Agathocles Tsatsoulis
Mar 17, 2009·International Journal of Immunogenetics·H Hadj-KacemS Péraldi-Roux
Mar 12, 2002·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·L H B BoechatR L Zollner
Dec 13, 2003·Endocrine Reviews·Bellur S PrabhakarTerry J Smith
Oct 9, 2009·Immunological Investigations·Maria AndrikoulaAgathocles Tsatsoulis
Nov 26, 2004·Molecular Endocrinology·Emese MezosiJames R Baker
Nov 25, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kemin ChenHelen Braley-Mullen
Jul 19, 2018·International Journal of Endocrinology·Jessica Castro de VasconcelosDenise Engelbrecht Zantut-Wittmann
Dec 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yongzhong WeiHelen Braley-Mullen
Apr 30, 2021·Immunologic Research·Claudia TetiMarcello Bagnasco

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Thyroiditis

Autoimmune thyroiditis is an inflammatory disease of thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. Discover the latest research on autoimmune thyroiditis here.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

European Journal of Endocrinology
M Andrikoula, Agathocles Tsatsoulis
Thyroid : Official Journal of the American Thyroid Association
Y HiromatsuK Nonaka
Clinical Immunology and Immunopathology
P L Arscott, J R Baker
© 2021 Meta ULC. All rights reserved