Differential regulation of IgG-NMO autoantibodies on S100Beta protein and disability in relapsing neuromyelitis optica

Neuroimmunomodulation
Maria A Robinson-AgramonteOnofre D Gomes de Souza

Abstract

Neuromyelitis optica (NMO), an uncommon central nervous system (CNS) demyelinating disease, produces transverse myelitis and severe optic neuritis. IgG-NMO autoantibody, a specific immunoglobulin binding aquaporin-4 water channel protein, confirms that NMO is a different entity to multiple sclerosis. Parallel to cytokine down-regulations found in serum of relapsing-NMO (rNMO) patients, it has been reported that IgG-NMO may also confer a worse course of the disease in r-NMO Caribbean patients. In this study, we were interested in exploring the influence of IgG-NMO autoantibody on S100beta levels and clinical parameters from serum of r-NMO patients. Serum samples from 24 rNMO patients and 10 controls were evaluated. The reduction of S100beta observed in r-NMO patients was not significant compared to controls; and no differences were present regarding IgG-NMO immunoreactivity. At the same time, a significant correlation was also observed between IgG-NMO autoantibody serum detection and EDSS (Expanded Disability Status Scale) in rNMO. These results corroborate a differential regulation of IgG-NMO autoantibodies on the S100beta glial marker and on the disability present in rNMO patients.

Citations

Nov 25, 2011·Expert Review of Clinical Pharmacology·Mario Landys ChovelAna María Hernández
Jan 16, 2014·Autoimmunity Reviews·Axel Petzold, Gordon T Plant
Mar 14, 2012·Journal of the Neurological Sciences·Mithu StoroniAxel Petzold
Nov 13, 2012·Brain Research·Caroline ZanottoCarlos-Alberto Gonçalves

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