Differential regulation of luteinizing hormone, follicle-stimulating hormone, and free alpha-subunit secretion from the gonadotrope by gonadotropin-releasing hormone (GnRH): evidence from the use of two GnRH antagonists

The Journal of Clinical Endocrinology and Metabolism
J E HallW F Crowley

Abstract

To examine the differential regulation of glycoprotein hormone secretion from the gonadotrope by GnRH, the Nal-Glu GnRH antagonist was administered to euthyroid women in the early follicular phase (days 1-5) of the menstrual cycle, and the results compared to previous studies with the Nal-Arg GnRH antagonist. After a 4-h period of baseline sampling at a frequency of every 10 min, a single sc dose of the GnRH antagonist was administered to each subject. Frequent sampling continued for 8 h, followed by hourly sampling for a further 16 h. LH, FSH, and free alpha-subunit were measured serially in assays with high specificity. There was a 90% concordance of LH and free alpha-subunit pulses during the baseline sampling period. Pulsatile secretion of LH and free alpha-subunit was immediately abolished at the highest dose of the Nal-Glu antagonist for at least 8 h. The maximum percent suppression of LH after administration of the Nal-Glu GnRH antagonist was 70 +/- 4%, 80 +/- 4%, and 83 +/- 1% at doses of 15, 50, and 150 micrograms/kg, respectively, compared to 51 +/- 10%, 70 +/- 5%, and 69 +/- 5% at doses of 50, 150, and 500 micrograms/kg Nal-Arg antagonist. Decreases in FSH were 28 +/- 2%, 32 +/- 7%, and 39 +/- 2%, with increasing dos...Continue Reading

Associated Clinical Trials

Apr 4, 2007·Janet E. Hall, MD

Citations

Jun 30, 1994·European Journal of Obstetrics, Gynecology, and Reproductive Biology·A CanoC Armero
Dec 26, 2001·Archives of Medical Research·V Padmanabhan, T P Sharma
Jan 29, 1999·Endocrinology and Metabolism Clinics of North America·F J HayesW F Crowley
Sep 27, 2001·Endocrinology and Metabolism Clinics of North America·J E Hall, S Gill
Apr 1, 1996·Baillière's Clinical Endocrinology and Metabolism·S G Soule
Jul 19, 1994·Proceedings of the National Academy of Sciences of the United States of America·J E HallW F Crowley
Feb 25, 2011·The Journal of Clinical Endocrinology and Metabolism·Kara M KlingmanJanet E Hall
May 29, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M C OliveiraJ G Vieira
May 28, 1993·Annals of the New York Academy of Sciences·J E HallW F Crowley
Jul 11, 2009·Endocrine Reviews·F J BroekmansB C Fauser
Dec 1, 2001·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·M ZarkovićM Drezgić

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