PMID: 11342152May 9, 2001Paper

Differential regulation of Na(+),K(+)-ATPase and the Na(+)-coupled glucose transporter in hypertensive rat kidney

Biochimica Et Biophysica Acta
A IkariY Suketa

Abstract

Several Na(+) transporters are functionally abnormal in the hypertensive rat. Here, we examined the effects of a high-salt load on renal Na(+),K(+)-ATPase and the sodium-coupled glucose transporter (SGLT1) in Dahl salt-resistant (DR) and salt-sensitive (DS) rats. The protein levels of Na(+),K(+)-ATPase and SGLT1 in the DS rat were the same as those in the DR rat, and were not affected by the high-salt load. In the DS rat, a high-salt load decreased Na(+),K(+)-ATPase activity, and this decrease coincided with a decrease in the apparent Mechaelis constant (K(m)) for ATP, but not with a change of maximum velocity (V(max)). On the contrary, a high-salt load increased SGLT1 activity in the DS rat, which coincided with an increase in the V(max) for alpha-methyl glucopyranoside. The protein level of phosphorylated tyrosine residues in Na(+),K(+)-ATPase was decreased by the high-salt load in the DS rat. The amount of phosphorylated serine was not affected by the high-salt load in DR rats, and could not be detected in DS rats. On the other hand, the amount of phosphorylated serine residues in SGLT1 was increased by the high-salt load. However, the phosphorylated tyrosine was the same for all samples. Therefore, we concluded that the hig...Continue Reading

References

Nov 1, 1979·Journal of Biochemistry·O Urayama, M Nakao
Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·A M BertorelloP Greengard
Jun 1, 1991·The American Journal of Physiology·K AmslerB A Hemmings
Jul 1, 1989·American Journal of Hypertension·M L MelziA Aperia
Dec 15, 1986·Biochemical and Biophysical Research Communications·K TakaoriT Takeda
May 1, 1995·Journal of Hypertension·A M AbdelrahmanF H Leenen
May 1, 1993·Hypertension·D RosskopfW Siffert
Jan 26, 1996·The Journal of Biological Chemistry·E TurkE M Wright
Apr 26, 1996·The Journal of Biological Chemistry·M Panayotova-HeiermannE M Wright
Jun 1, 1996·Pflügers Archiv : European journal of physiology·C M VázquezV Ruiz-Gutierrez
May 18, 1999·The American Journal of Physiology·S Vayro, M Silverman

❮ Previous
Next ❯

Citations

Feb 18, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Daniele CanaleRoberto Zatz
Jun 22, 2007·Clinical and Experimental Pharmacology & Physiology·Veronika JavorkováNorbert Vrbjar
Apr 21, 2007·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·S IannelloF Belfiore
Oct 2, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Chahrazed El HamelMichel Cogné
Jan 10, 2003·The Japanese Journal of Physiology·Akira Ikari, Yasunobu Suketa
Aug 22, 2002·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Yasunobu Suketa
Jul 16, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yasuhiro KimuraRandal K Buddington
May 13, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Alfonso MateJoana M Planas
Jun 4, 2008·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Yasunobu Suketa
Sep 25, 2003·American Journal of Physiology. Renal Physiology·Rocío BautistaBruno Escalante
Jun 12, 2002·Biochemical and Biophysical Research Communications·Akira IkariYasunobu Suketa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.