PMID: 11925461Apr 2, 2002Paper

Differential regulation of porcine hepatic IGF-I mRNA expression and plasma IGF-I concentration by a low lysine diet

The Journal of Nutrition
M KatsumataM J Dauncey

Abstract

The influence of dietary lysine on hepatic insulin-like growth factor-I (IGF-I) gene expression and plasma IGF-I level was investigated. Two male 6-wk-old pigs from each of six litters were used. Each littermate was assigned to one of two diets, control or low lysine (LL), that were isoenergetic and similar in protein content and provided 14.3 MJ digestible energy/kg for both diets, 185 g protein/kg for the control diet and 180 g protein/kg for the LL diet. The control diet contained all essential amino acids in the recommended amounts, including 11.5 g lysine/kg. The LL diet was similar but contained only 7 g lysine/kg. Pigs were pair-fed these diets for 3 wk. Growth rates and feed efficiencies of pigs fed the LL diet were significantly lower than those of pigs fed the control diet (P < 0.01). Plasma IGF-I levels in pigs fed the LL diet were 52% lower than in those fed the control diet (P < 0.01), and the LL group also had lower plasma IGF-binding protein-3 (IGFBP3) levels (P < 0.05). Despite the strikingly lower plasma IGF-I in pigs fed the LL diet, hepatic IGF-I mRNA abundance did not differ between the two treatment groups. We conclude that the reduction in plasma IGF-I caused by reduced dietary lysine may have been due in ...Continue Reading

References

Jan 1, 1992·Hormone Research·C AlvarezA M Pascual-Leone
Jan 1, 1994·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M J DaunceyD Cattaneo
May 22, 1998·Progress in Nucleic Acid Research and Molecular Biology·L S PhillipsB C Villafuerte
Jul 31, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M KatsumataM J Dauncey

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Citations

Oct 31, 2012·The British Journal of Nutrition·Shibani GhoshRicardo Uauy
Jan 1, 2011·Journal of Nutritional Science and Vitaminology·Aiko IshidaMasaya Katsumata
Jan 24, 2013·International Journal of Cancer. Journal International Du Cancer·Konstantinos K TsilidisTimothy J Key
Nov 7, 2012·Animal Science Journal = Nihon Chikusan Gakkaihō·Aiko IshidaMasaya Katsumata
Mar 24, 2016·Food and Nutrition Bulletin·Shibani Ghosh
May 21, 2016·Animal Science Journal = Nihon Chikusan Gakkaihō·Genya WatanabeShinobu Fujimura
Sep 6, 2014·Journal of Applied Genetics·Eliane GasparinoAdhemar Rodriges de Oliveira Neto
Jan 29, 2011·Animal Science Journal = Nihon Chikusan Gakkaihō·Masaya Katsumata
May 22, 2010·Journal of Animal Physiology and Animal Nutrition·Y C Zhang, F C Li
Mar 7, 2021·Animals : an Open Access Journal From MDPI·Pablo Jesús Marín-García, Lola Llobat

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