Differential regulation of serum immunoreactive luteinizing hormone and bioactive follicle-stimulating hormone by testosterone in early pubertal boys

The Journal of Clinical Endocrinology and Metabolism
J M HassingI Z Beitins

Abstract

The microheterogeneity and bioassayable activity of serum FSH (B-FSH) can be regulated by exogenous GnRH in boys with idiopathic hypogonadotropic hypogonadism and by estrogen in a women with gonadal dysgenesis, presumably via hormonally mediated changes in the degree of FSH glycosylation. To test the hypothesis that testosterone (T) regulates the circulating forms of B-FSH, we raised the serum T levels of early pubertal boys to adult levels. In this model, high dose T inhibits the pubertal nocturnal augmentation of LH secretion, apparently through decreased GnRH secretion. This model allowed us to test a second hypothesis, that B-FSH is a sensitive indicator of hypothalamic GnRH release. The boys were studied on two consecutive weekends, during which they received either saline (S) or T infusions. Beginning at noon on the study day, after an overnight acclimatization, the boys received either S or T at 33% or 100% of the adult male production rate. Blood was sampled from 2000-0800 at 10-min intervals for immunoactive LH and FSH (I-FSH) and for B-FSH, as determined by the in vitro Sertoli cell aromatase induction assay, and at 30-min intervals for T. Gonadotropin levels were analyzed as mean hourly or 3-h concentrations and as p...Continue Reading

Citations

May 1, 1997·The Journal of Steroid Biochemistry and Molecular Biology·G R BrissonM J Castillo
Dec 1, 1990·Journal of Neuroendocrinology·J D Veldhuis, M L Johnson
Jun 1, 1996·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J D Veldhuis
Sep 1, 1991·Clinical Endocrinology·A TsatsoulisW R Robertson
Dec 1, 1991·Journal of Endocrinological Investigation·M Simoni, E Nieschlag

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