Differential regulation of the insulin-like growth factor II mRNA-binding protein genes by architectural transcription factor HMGA2

FEBS Letters
Jan R BrantsMarleen M R Petit

Abstract

The developmentally regulated architectural transcription factor, high mobility group A2 (HMGA2), is involved in growth regulation and plays an important role in embryogenesis and tumorigenesis. Little is known, however, about its downstream targets. We performed a search for genes of which expression is strongly altered during embryonic development in two HMGA2-deficient mouse strains, which display a pygmy-phenotype, as compared to wild-type mice. We found that the insulin-like growth factor II mRNA-binding protein 2 gene (IMP2), but not its family members IMP1 and IMP3, was robustly downregulated in mutant E12.5 embryos. Furthermore, we show that wild-type HMGA2 and its tumor-specific truncated form have opposite effects on IMP2 expression. Our results clearly indicate that HMGA2 differentially regulates expression of IMP family members during embryogenesis.

References

Oct 15, 1996·Nucleic Acids Research·X ZhouK Chada
Apr 1, 1997·Molecular and Cellular Biology·A F RossR H Singer
Mar 12, 1998·American Journal of Clinical Pathology·J L Hess
Sep 3, 1999·Advances in Anatomic Pathology·G Tallini, P Dal Cin
Mar 31, 2000·Nature Genetics·A Anand, K Chada
Jun 19, 2001·Biochimica Et Biophysica Acta·R Reeves, L Beckerbauer
Jun 21, 2002·BioTechniques·László G PuskásPaul Van Hummelen
Nov 21, 2002·The Journal of Biological Chemistry·Marleen M R PetitWim J M Van de Ven
Apr 16, 2003·Biochemistry·Barbara NoroGuidalberto Manfioletti
Dec 3, 2003·Molecular and Cellular Biology·Michela A TessariGuidalberto Manfioletti
May 4, 2004·Molecular and Cellular Biology·Thomas V O HansenFinn C Nielsen

❮ Previous
Next ❯

Citations

Oct 17, 2012·Cellular and Molecular Life Sciences : CMLS·Jessica L BellStefan Hüttelmaier
Jun 29, 2010·Nature Genetics·Benjamin F VoightUNKNOWN GIANT Consortium
Dec 17, 2004·Biology of the Cell·Joel K Yisraeli
Oct 20, 2010·Molecular and Cellular Biology·Selim BoudoukhaAnna Polesskaya
Apr 20, 2012·American Journal of Physiology. Renal Physiology·Valerie SchaefferChristine K Abrass
Apr 17, 2008·Molecular Cancer Therapeutics·Xuefei CaoDavid K Ann
Aug 2, 2011·European Journal of Endocrinology·Darya Gorbenko del BlancoAnita C S Hokken-Koelega
Mar 26, 2014·BMC Biology·Indrabahadur SinghGuillermo Barreto
Sep 30, 2010·Current Diabetes Reports·Martijn van de Bunt, Anna L Gloyn
May 2, 2012·Stem Cell Reviews and Reports·Amir MorshediPeter Dröge
Jan 27, 2016·Trends in Endocrinology and Metabolism : TEM·Elwin Tan Jun-HaoNg Shyh-Chang
Sep 26, 2015·British Journal of Haematology·Zhouying WuMariko Eguchi
Jan 22, 2013·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Yuki FujiiYukiko Gotoh
Nov 5, 2014·Frontiers in Cell and Developmental Biology·Nihan OzturkGuillermo Barreto
Sep 11, 2004·FEBS Letters·Riccardo SgarraVincenzo Giancotti
Aug 5, 2017·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Ayaka KimuraKinichi Nakashima
Sep 28, 2016·Journal of Cell Science·Xingyu ZhouDelin Mo
Sep 25, 2018·The Journal of Clinical Endocrinology and Metabolism·Miao LiZi-Jiang Chen
Jan 24, 2014·Endocrine Reviews·Kyriaki S AlatzoglouMehul T Dattani
Jan 23, 2020·International Journal of Molecular Sciences·Robert Vignali, Silvia Marracci
Aug 15, 2020·Frontiers in Oncology·Barbara SchrörsMartin Löwer
Jul 1, 2020·Acta Neuropathologica·Sander LamboMarcel Kool
Aug 16, 2005·Journal of Animal Science·C S Lin, C W Hsu
Jun 1, 2013·Cancer Research·Asahiro MorishitaKiran Chada
Mar 10, 2005·Molecular Cancer Research : MCR·Koen R M O CrombezMarleen M R Petit
Mar 7, 2021·Genes·Behzad MansooriBehzad Baradaran
Jun 2, 2021·The Journal of Clinical Endocrinology and Metabolism·Junguo CaoHong Yan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.