Abstract
Induction therapy is associated with excellent short-term kidney graft outcome. The aim of this study was to evaluate differences in the intragraft transcriptome after successful induction therapy using two rabbit antithymocyte globulins. The expression of 376 target genes involved in tolerance, inflammation, T- and B-cell immune response, and apoptosis was evaluated using the quantitative real-time reverse-transcriptase polymerase chain reaction (2(-ΔΔCt)) method in kidney graft biopsies with normal histological findings and stable renal function, 3 months posttransplantation after induction therapy with Thymoglobulin, ATG-Fresenius S (ATG-F), and a control group without induction therapy. The transcriptional pattern induced by Thymoglobulin differed from ATG-F in 18 differentially expressed genes. Down-regulation of genes involved in the nuclear factor-κB pathway (TLR4, MYD88, and CD209), costimulation (CD80 and CTLA4), apoptosis (NLRP1), chemoattraction (CCR10), and dendritic cell function (CLEC4C) was observed in the biopsies from patients treated with Thymoglobulin. A hierarchical clustering analysis clearly separated the Thymoglobulin group from the ATG-F group, while the control group had a similar profile as the Thymogl...Continue Reading
References
Mar 15, 1994·Transplantation·L M RebellatoJ M Thomas
Apr 29, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·D ThibaudinF Berthoux
Jul 20, 1999·Kidney International·G K RanganD C Harris
Jun 1, 2000·Transplantation·A O ZuckermannG Laufer
Mar 10, 2001·Transplantation·X PrévilleJ P Revillard
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Feb 18, 2003·Clinical Transplantation·Karsten MidtvedtInge B Brekke
Mar 18, 2003·Transplantation·Marie-Cécile MichalletJean-Pierre Revillard
Mar 28, 2003·Transplantation·Bernard CharpentierMichèle Kessler
Jun 11, 2003·Clinical Transplantation·Robert J StrattaA Osama Gaber
Sep 12, 2003·Transplant Immunology·Anne HutchingsJudith M Thomas
Apr 17, 2004·Transplantation·Didier DuclouxJean-Marc Chalopin
Feb 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·An De CreusAngus W Thomson
Feb 24, 2006·Transplantation·Jagdeep Obhrai, Daniel R Goldstein
Mar 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Keisuke MinamimuraTakashi Maki
May 16, 2006·Transplantation·Gerhard OpelzBernd Döhler
Aug 18, 2006·Journal of the American Society of Nephrology : JASN·Marta LopezNader Najafian
Feb 17, 2007·Bioinformatics·Jelle J Goeman, Peter Bühlmann
Feb 24, 2007·Transplantation·Cord NaujokatVolker Daniel
Apr 7, 2007·Transplantation·Stephanie LouisJean-Paul Soulillou
Apr 26, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·B SawitzkiH-D Volk
Sep 20, 2007·Journal of Clinical Immunology·Volker DanielGerhard Opelz
Nov 22, 2007·Lancet·Carla AbouZahrSiwei Zhang
Feb 6, 2008·Blood·Xingmin FengNeal S Young
Dec 2, 2008·Transplant Immunology·A Beiras-FernandezE Thein
Feb 21, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Beatriz Sánchez-EspiridiónUNKNOWN Spanish Hodgkin's Lymphoma Study Group
Mar 25, 2009·Transplantation·Jean-Hugues DalleMichel Duval
Jun 9, 2009·Transplantation·Masahito OgawaMitsuaki Isobe
Jul 24, 2010·Journal of the American Society of Nephrology : JASN·Ana Belen SanzAlberto Ortiz
Citations
Jul 24, 2013·Expert Opinion on Biological Therapy·Afshin GharekhaniHossein Khalili
Oct 5, 2013·Transplantation·Mariana WohlfahrtovaOndrej Viklicky
Aug 2, 2014·Transplantation·R Brian StevensLucile E Wrenshall
May 6, 2016·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Alena ParikovaRaymond T Krediet
Jun 7, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ondrej ViklickyIrena Brabcova
Sep 8, 2016·American Journal of Physiology. Endocrinology and Metabolism·Irena TýcováOndřej Viklický
Apr 23, 2020·Frontiers in Immunology·Turun SongTao Lin