Differential regulation of the OASL and OAS1 genes in response to viral infections

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
Jesper MelchjorsenRune Hartmann

Abstract

The 2'-5' oligoadenylate synthetase (OAS) family consist of three genes encoding active OAS enzymes (OAS1-3) and an OAS-Like (OASL) gene encoding an inactive protein. The transcription of all four members of this family is actively induced by interferon (IFN), but so far no attempt to systematically analyze the expression of these genes during viral infection has been made. We analyzed the expression of the human OAS1 and OASL genes in response to infection with Sendai virus or Influenza A virus. Surprisingly, we found a marked difference in the expression pattern of these genes. Our data showed that the OASL gene is rapidly induced in response to viral infection and that this induction is mediated by IFN regulatory factor 3 (IRF-3). In contrast to the OASL gene, the induction of the OAS1 gene by virus infection was lower, and did require a functional type I IFN response. The pronounced difference in gene regulation between the OAS1 and OASL genes agrees with a functional difference between these genes, which must exist as a consequence of the lack of the 2-5A synthetase activity of the OASL protein. Furthermore, the behavior of the OASL gene is consistent with the behavior of an antiviral gene.

References

Apr 2, 2013·Developmental and Comparative Immunology·Peng ZhouMichelle L Baker
Jan 6, 2010·The Journal of Biological Chemistry·Nan WangKui Li
Dec 15, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Helle KristiansenRune Hartmann
Jun 7, 2014·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Robert H Silverman, Susan R Weiss
Apr 26, 2012·The International Journal of Biochemistry & Cell Biology·Xuancheng GuoErguang Li
Dec 12, 2012·Molecular Immunology·Megan R W BarberKatharine E Magor
Apr 27, 2012·Molecular Immunology·Hillary A VandervenKatharine E Magor
May 1, 2015·Nucleic Acids Research·Mikkel Søes IbsenRune Hartmann
Dec 18, 2014·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Karthiga ThavachelvamHelle Kristiansen
Oct 2, 2014·Journal of Veterinary Science·Yuqiang ChengJianhe Sun
Mar 7, 2015·Experimental & Molecular Medicine·Un Yung ChoiYoung-Joon Kim
Aug 2, 2016·Nature Genetics·Victoria HoreJonathan Marchini
Sep 25, 2016·Biochimica Et Biophysica Acta·Maria AnastasinaDenis E Kainov
Nov 4, 2017·Integrative Biology : Quantitative Biosciences From Nano to Macro·Sultan DoğanayTaekjip Ha
Jul 19, 2014·Nature Reviews. Immunology·Veit HornungKarl-Peter Hopfner
Sep 30, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mirco SchmolkeStephan Ludwig
Apr 8, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jesper MelchjorsenMartin Tolstrup
Jun 6, 2017·Frontiers in Cellular and Infection Microbiology·Gina LeischingBienyameen Baker

Citations

Nov 1, 1989·Molecular and Cellular Biology·S PellegriniGeorge R Stark
Feb 24, 1995·The Journal of Biological Chemistry·Beihua Dong, Robert H Silverman
Feb 21, 1998·Nucleic Acids Research·T HeinemeyerN A Kolchanov
Oct 6, 1998·Annual Review of Biochemistry·George R StarkR D Schreiber
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·S D DerRobert H Silverman
Aug 10, 2000·Journal of Virology·J TalonAdolfo García-Sastre
Nov 25, 2000·Cellular and Molecular Life Sciences : CMLS·J JustesenN O Kjeldgaard
May 18, 2001·Biochemical and Biophysical Research Communications·T NakayaTadatsugu Taniguchi
Sep 7, 2001·Annual Review of Microbiology·G C Sen
Apr 25, 2002·Proceedings of the National Academy of Sciences of the United States of America·Kristi L PetersGanes C Sen
Dec 7, 2002·Nature Immunology·Paul SheppardKevin M Klucher
Dec 17, 2002·Nature Immunology·Sergei V KotenkoRaymond P Donnelly
May 4, 2004·International Immunopharmacology·Sergei V Kotenko, Jerome A Langer
Aug 26, 2006·Nature Reviews. Immunology·Kenya Honda, Tadatsugu Taniguchi
Sep 19, 2006·Immunity·Anette H H van Boxel-DezaireGeorge R Stark
Sep 29, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sean E DoyleKevin M Klucher
Jul 27, 2007·Nature·Krishnamurthy MalathiRobert H Silverman
Nov 1, 2007·Current Topics in Microbiology and Immunology·H A Young, J H Bream
Jan 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Johanna RintahakaSampsa Matikainen

Related Concepts

Tumor Virus Infections
Virus Diseases
Enzymes, antithrombotic
OAS1 protein, human
Influenza
Human leukocyte interferon
Citrullinemia
Reverse Transcriptase Polymerase Chain Reaction
Interferon
Interferon Regulatory Factor 3

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