PMID: 2847035Oct 1, 1988

Differential regulation of the two genes encoding Saccharomyces cerevisiae cytochrome c oxidase subunit V by heme and the HAP2 and REO1 genes

Molecular and Cellular Biology
C E TruebloodR O Poyton


In Saccharomyces cerevisiae, the COX5a and COX5b genes encode two forms of cytochrome c oxidase subunit V, Va and Vb. We report here that heme increases COX5a expression and decreases COX5b expression and that the HAP2 and REO1 genes are involved in positive regulation of COX5a and negative regulation of COX5b, respectively. Heme regulation of COX5a and COX5b may dictate which subunit V isoform is available for assembly into cytochrome c oxidase under conditions of high- and low-oxygen tension.


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Related Concepts

Cytochrome c Oxidase Subunit VIa
Genes, Fungal
Poly(A) Tail
Saccharomyces cerevisiae
Transcription, Genetic
Northern Blot

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