PMID: 2847035Oct 1, 1988

Differential regulation of the two genes encoding Saccharomyces cerevisiae cytochrome c oxidase subunit V by heme and the HAP2 and REO1 genes

Molecular and Cellular Biology
C E TruebloodR O Poyton

Abstract

In Saccharomyces cerevisiae, the COX5a and COX5b genes encode two forms of cytochrome c oxidase subunit V, Va and Vb. We report here that heme increases COX5a expression and decreases COX5b expression and that the HAP2 and REO1 genes are involved in positive regulation of COX5a and negative regulation of COX5b, respectively. Heme regulation of COX5a and COX5b may dictate which subunit V isoform is available for assembly into cytochrome c oxidase under conditions of high- and low-oxygen tension.

Citations

Jun 16, 2015·Clinical and Experimental Nephrology·Zdenek TumaMartin Matejovic
Jan 1, 1991·European Journal of Biochemistry·C SacconeB Kadenbach
Oct 1, 2009·Nitric Oxide : Biology and Chemistry·Sruti Shiva
Jul 1, 1989·European Journal of Biochemistry·L A Grivell
Jan 1, 1988·Annals of the New York Academy of Sciences·R O PoytonL E Farrell
Jun 5, 2008·Biochimica Et Biophysica Acta·Antoni BarrientosFlavia Fontanesi
Apr 5, 2008·Proceedings of the National Academy of Sciences of the United States of America·Pablo R CastelloR O Poyton
Apr 1, 1996·Trends in Biochemical Sciences·R HamptonJ Rine
Apr 4, 1998·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·F P Ruggiero, J B Sheffield
Sep 4, 2012·Antioxidants & Redox Signaling·Myriam BourensAntoni Barrientos
Jan 1, 1996·Folia Microbiologica·P Haviernik, G J Laquin
Jun 9, 2006·American Journal of Physiology. Cell Physiology·Flavia FontanesiAntoni Barrientos
Jun 6, 1997·The Journal of Biological Chemistry·Patricia V BurkeR O Poyton
Mar 2, 2017·Oxidative Medicine and Cellular Longevity·Jochen HinkelbeinFabrizio Cirillo
Mar 18, 2010·Physiological Genomics·A G LittleC D Moyes
Jul 10, 2019·Oxidative Medicine and Cellular Longevity·Xiaonan ZhangStig Linder

Related Concepts

Cytochrome c Oxidase Subunit VIa
Genes, Fungal
Heme
Dioxygen
Poly(A) Tail
Saccharomyces cerevisiae
Transcription, Genetic
Northern Blot

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