PMID: 9418958Jan 7, 1998Paper

Differential regulation of the zinc finger genes Krox-20 and Krox-24 (Egr-1) suggests antagonistic roles in Schwann cells

Journal of Neuroscience Research
P TopilkoP Charnay

Abstract

Krox-20 and Krox-24 (Egr-1) encode closely related zinc finger transcription factors, which interact with the same DNA target sequences. Krox-20 is required for myelination in the peripheral nervous system. Using lacZ knock-in mutant mouse lines as well as immunohistochemical analyses, we have studied the expression of Krox-20 and Krox-24 in the Schwann cell lineage during normal development and following nerve lesion in the mouse and in human neuropathies. During embryogenesis, the two genes are expressed in a successive and mutually exclusive manner, Krox-24 being restricted to Schwann cell precursors and Krox-20 to mature Schwann cells. At birth, Krox-24 is reactivated and the two genes are coexpressed. In the adult, Krox-20 is expressed in myelinating cells, while Krox-24 is restricted to nonmyelinating cells. Following nerve lesion, Krox-24 is strongly induced in Schwann cells, reinforcing the link between its expression and the nonmyelinating and/or proliferative state, whereas Krox-20 is downregulated. These data are consistent with Krox-20 and Krox-24 playing antagonistic roles during the development of the Schwann cell lineage. In particular, their balance of expression might participate in the choice between myelinati...Continue Reading

References

Oct 1, 1992·Current Opinion in Neurobiology·K R Jessen, R Mirsky
May 25, 1992·Nucleic Acids Research·C Vesque, P Charnay
Apr 1, 1991·Journal of the Neurological Sciences·G L MancardiD Zaccheo
Sep 14, 1990·Science·E S MonukiG Lemke
Jul 1, 1990·Molecular and Cellular Biology·P LemaireP Charnay
Jan 1, 1990·Annual Review of Neuroscience·J W Fawcett, R J Keynes
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·B Christy, D Nathans
Dec 1, 1989·Neuron·E S MonukiG Lemke
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·P LemaireP Charnay
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·B A ChristyD Nathans
Jul 18, 1995·Proceedings of the National Academy of Sciences of the United States of America·M W RussoJ Milbrandt
May 1, 1993·Journal of Neuroscience Research·J J ArchelosH P Hartung
Jul 1, 1993·Mechanisms of Development·E S MonukiG Lemke
Apr 1, 1995·Molecular and Cellular Biology·A H Swirnoff, J Milbrandt
Jul 26, 1996·Science·M JaegleD Meijer
Apr 1, 1996·Molecular and Cellular Neurosciences·G Lemke
Feb 1, 1996·Trends in Biochemical Sciences·M VandrommeA Fernandez
Jan 1, 1996·Molecular and Cellular Neurosciences·P TopilkoP Charnay
Aug 1, 1996·Molecular and Cellular Neurosciences·P TopilkoP Charnay
Oct 1, 1953·Journal of Neuropathology and Experimental Neurology·H KLUVER, E BARRERA
Jan 1, 1989·The Western Journal of Medicine·V R Hentz

❮ Previous
Next ❯

Citations

Mar 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Anja Krones-HerzigDan Mercola
Dec 22, 2007·BMC Molecular Biology·Rajini SrinivasanJohn Svaren
May 6, 2008·The Journal of Biological Chemistry·Gennifer M MagerJohn Svaren
Jun 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·André HeinenPatrick Küry
Jun 19, 2008·Genes & Development·Karim NadraRoman Chrast
Jul 19, 2008·Neuron Glia Biology·Erin A JonesJohn Svaren
Feb 21, 2009·Cell Death and Differentiation·K B BoyleK Siddle
Jun 3, 2009·The Journal of Biological Chemistry·Sung-Wook Jang, John Svaren
Dec 15, 2010·PloS One·Carlos RiverosUNKNOWN ANZgene Multiple Sclerosis Genetics Consortium
Feb 4, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Holly HungJohn Svaren
Apr 12, 2012·Nucleic Acids Research·Rajini SrinivasanJohn Svaren
Dec 10, 1999·Annals of the New York Academy of Sciences·S M NicholsonR Bruzzone
Nov 12, 2016·International Journal of Molecular Sciences·Namhee JungSung-Chul Jung
Dec 11, 2007·Acta histochemica·Ugo Ndubaku, Maria Elena de Bellard
Nov 29, 2016·Journal of Neurochemistry·José F Rodríguez-MolinaJohn Svaren
Jul 13, 2017·Glia·Angélique BoerboomRachelle Franzen
Mar 14, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Richard GrosePaul Martin
Oct 13, 2001·Journal of Neuroscience Research·S M NicholsonR Bruzzone
Nov 11, 2017·Glia·Jorge B Aquino, Romina Sierra
Jul 22, 1998·Microscopy Research and Technique·K R Jessen, R Mirsky
Mar 26, 2013·PloS One·Judith A Blake, Melanie R Ziman
Nov 4, 2010·Journal of Neurochemistry·Sung-Wook JangJohn Svaren
Oct 1, 1999·Annals of the New York Academy of Sciences·John KamholzMichael Shy
Sep 8, 2012·Journal of Clinical Immunology·André HeinenPatrick Küry
Jun 26, 2013·Journal of Molecular Neuroscience : MN·Akvilė JarmalavičiūtėAugustas Pivoriūnas
Jan 10, 2014·Developmental Neurobiology·Carolina UggentiAda Maria Tata
Jul 7, 2007·Physiological Reviews·Xiaoyan ZhuMichael G Rosenfeld
Jan 23, 1999·The Journal of Biological Chemistry·P R Mittelstadt, J D Ashwell
Mar 10, 2011·PloS One·Maria-Jesus Latasa, Jose Miguel Cosgaya
May 2, 2020·Human Molecular Genetics·Harrison PanteraJohn Svaren
Jul 15, 2006·Molecular Endocrinology·Lori T RaetzmanSally A Camper
Jan 12, 2020·Nature Communications·Nadjet GacemNadege Bondurand
Feb 8, 2020·Scientific Reports·Elen Torres-MejíaSabrina C Desbordes
Aug 19, 2006·The Journal of Biological Chemistry·Frederique RufStuart C Sealfon

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.