Differential Regulation of Toll-Like Receptor-Mediated Cytokine Production by Unfolded Protein Response

Oxidative Medicine and Cellular Longevity
Sena KimHun Taeg Chung

Abstract

The ability of the host immune response is largely mediated by the proinflammatory cytokine production. Physiological and pathological conditions of endoplasmic reticulum (ER) trigger unfolded protein response and contribute to the development or pathology of inflammatory diseases. Under ER stress, unfolded protein response (UPR) signaling pathways participate in upregulating inflammatory cytokine production via NF-kappaB, MAPK, and GSK-3β. Moreover, it has been suggested that ER stress crosstalks with toll-like receptor (TLR) signaling pathway to promote the production of proinflammatory cytokines. In addition, TLR stimulation can lead to UPR activation to promote inflammation. In this review, we will cover how proinflammatory cytokine production by UPR signaling can be induced or amplified in the presence or absence of TLR activation.

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Citations

Jul 3, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Guosheng JiangLijuan Wang
Dec 23, 2020·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Min LiHuabin Li
Dec 17, 2020·Frontiers in Immunology·Sanchez Preethi EugeneJamma Trinath

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Methods Mentioned

BETA
ubiquitination
chemical stress
nuclear translocation

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