Differential regulation of type I and type VIII Ca2+-stimulated adenylyl cyclases by Gi-coupled receptors in vivo.

The Journal of Biological Chemistry
M D NielsenD R Storm

Abstract

Coupling of intracellular Ca2+ to cAMP increases may be important for some forms of synaptic plasticity. The type I adenylyl cyclase (I-AC) is a neural-specific, Ca2+-stimulated enzyme that couples intracellular Ca2+ to cAMP increases. Since optimal cAMP levels may be crucial for some types of synaptic plasticity, mechanisms for inhibition of Ca2+-stimulated adenylyl cyclases may also be important for neuroplasticity. Here we report that Ca2+ stimulation of I-AC is inhibited by activation of Gi-coupled somatostatin and dopamine D2L receptors. This inhibition is due primarily to Gialpha and not betagamma subunits since coexpression of betagamma-binding proteins with I-AC did not affect somatostatin inhibition. However, betagamma released from Gs did inhibit I-AC, indicating that the enzyme can be inhibited by betagamma in vivo. Interestingly, type VIII adenylyl cyclase (VIII-AC), another Ca2+-stimulated adenylyl cyclase, was not inhibited by Gi-coupled receptors. These data indicate that I-AC and VIII-AC are differentially regulated by Gi-coupled receptors and provide distinct mechanisms for interactions between the Ca2+ and cAMP signal transduction systems. We propose that I-AC may be particularly important for synaptic plastic...Continue Reading

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Citations

Sep 18, 2013·Experimental Brain Research·Evelien GellynckKathleen Van Craenenbroeck
Jun 1, 2005·Cellular Signalling·Debora SteinerZvi Vogel
Dec 24, 1998·Molecular and Cellular Endocrinology·R E Carraway, S P Mitra
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Jun 1, 1997·Current Opinion in Neurobiology·Z Xia, D R Storm
Oct 31, 2002·The European Journal of Neuroscience·Jennifer R ChaoEric J Nestler
Nov 8, 2002·Journal of Neurochemistry·Hongbing WangDaniel R Storm
Jan 14, 2011·Science Translational Medicine·Hansen WangMin Zhuo
May 28, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hong XuJonathan A Raper
May 2, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ming ZhangHongbing Wang
Apr 12, 2006·Proceedings of the National Academy of Sciences of the United States of America·Russell E NichollsPatric K Stanton
Oct 18, 2014·Frontiers in Behavioral Neuroscience·Daria GusevaEvgeni Ponimaskin
Apr 15, 2000·Frontiers in Neuroendocrinology·F A Antoni
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Feb 28, 2003·Molecular Pharmacology·Hongbing Wang, Daniel R Storm
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Jul 4, 2001·The Journal of Biological Chemistry·S T WongK E Bornfeldt
Jun 29, 2018·Molecular Pharmacology·Monica Soto-VelasquezVal J Watts

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