PMID: 8583389Sep 1, 1995Paper

Differential relaxant responses of guinea-pig lung strips and bronchial rings to sodium nitroprusside: a mechanism independent of cGMP formation

The Journal of Pharmacy and Pharmacology
W S WongJ H Fleisch

Abstract

The biochemical mechanism subserving smooth muscle relaxant effects of sodium nitroprusside was examined on U46619, 9,11-dideoxy-9 alpha,11 alpha-methanoepoxy PGF2 alpha, precontracted guinea-pig lung strips and hilar bronchial rings. Lung strips were resistant to the relaxant action of sodium nitroprusside or sodium nitrite (NaNO2), whereas they markedly relaxed to 8-bromo-cyclic GMP (8-Br-cGMP), a membrane permeable analogue of cGMP. Precontracted bronchial rings completely relaxed to sodium nitroprusside, NaNO2, or 8-Br-cGMP in a concentration-dependent manner. Sodium nitroprusside (10 microM) substantially raised tissue cGMP level in lung strips. Conversely, sodium nitroprusside had no detectable effect on cGMP levels in bronchial rings. In the presence of 10 microM dipyridamole, an agent which preferentially inhibits cGMP-specific phosphodiesterase, cGMP levels in lung strips treated with sodium nitroprusside was significantly enhanced, but sodium nitroprusside demonstrated no relaxant effect on the preparations. However, dipyridamole potentiated sodium nitroprusside-induced precontracted bronchial ring relaxation without affecting the bronchial tissue cGMP level. In the presence of 10 microM LY83583 (6-anilino-5,8-quinoli...Continue Reading

References

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Citations

Jul 27, 2000·Journal of Cellular Physiology·J A CarvajalC P Weiner
Jun 29, 1999·British Journal of Pharmacology·J HjobergG Hedenstierna
Sep 8, 1998·The American Journal of Physiology·M Alonso-GaliciaR J Roman
Apr 27, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·X D LiuS I Rennard
Jul 19, 2000·American Journal of Physiology. Heart and Circulatory Physiology·C W SunR J Roman
Apr 11, 2002·Chemical Reviews·Anthony R Butler, Ian L Megson
Jun 3, 2021·Veterinary Sciences·Katrin RöhmJana Seifert

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