Differential release of prostacyclin and nitric oxide evoked from pulmonary and systemic vascular beds of the pig by endothelin-1

Prostaglandins, Leukotrienes, and Essential Fatty Acids
M G Clement, M Albertini

Abstract

The vascular effects of endothelin-1 (ET-1) and the release of prostacyclin and nitric oxide (NO) evoked by this peptide were analyzed in anesthetized, mechanically ventilated pigs. ET-1 induced biphasic responses in both the pulmonary and systemic vascular beds characterized by a transient hypotension followed by a long-lasting hypertension. To evaluate the involvement of prostacyclin and NO in the ET-1-dependent vascular response, we used indomethacin to block cyclooxygenase and NG-nitro-L-arginine methyl ester (L-NAME) to block NO synthase. The results show that the systemic hypotensive response to ET-1 is mediated by the release of prostanoids and NO, but these are not responsible for the pulmonary hypotension. Indomethacin reduced the hypertensive effect of ET-1, showing that this peptide can also activate release of vasoconstrictor cyclooxygenase metabolites. When L-NAME was administered after indomethacin, the pulmonary vasoconstrictor activity of ET-1 was counterbalanced by NO. By contrast, in pigs pretreated with indomethacin plus L-NAME ET-1 caused transient systemic vasoconstriction, followed by progressive reduction of vascular tone, probably because of release of vasodilator agents other than prostanoids or NO.

References

Mar 1, 1992·British Journal of Pharmacology·J R Fozard, M L Part
May 1, 1990·Journal of Cardiovascular Pharmacology·A R BaydounB Woodward
Jul 1, 1991·Journal of Cardiovascular Pharmacology·T Perreault, J De Marte
Jan 1, 1991·Journal of Cardiovascular Pharmacology·M TrybulecR J Gryglewski
Jan 1, 1989·Journal of Cardiovascular Pharmacology·C ThiemermannJ R Vane
Jan 1, 1989·Journal of Cardiovascular Pharmacology·T D WarnerJ R Vane
Jan 1, 1989·Journal of Cardiovascular Pharmacology·G A RaeJ R Vane
Jan 1, 1989·The Journal of Clinical Investigation·W L MillerJ C Burnett
Jan 17, 1989·European Journal of Pharmacology·T D WarnerJ R Vane
Apr 28, 1989·Biochemical and Biophysical Research Communications·H RakugiT Ogihara
Jul 18, 1989·European Journal of Pharmacology·P S LidburyJ R Vane
Nov 1, 1989·Circulation Research·J P Clozel, M Clozel
Aug 1, 1988·Trends in Pharmacological Sciences·S G Taylor, A H Weston
Mar 1, 1993·British Journal of Pharmacology·M E RogersonG H Neild
Oct 1, 1994·Naunyn-Schmiedeberg's Archives of Pharmacology·G G MatteraA Subissi
Nov 1, 1994·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M Albertini, M G Clement
Feb 1, 1994·British Journal of Pharmacology·J RiezebosP J Vallance
Apr 1, 1996·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M AlbertiniM G Clement
Jan 1, 1993·Mediators of Inflammation·M G ClementM Albertini
Jan 1, 1995·Mediators of Inflammation·M Clement, M Albertini

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Citations

Sep 24, 2002·Pharmacology & Therapeutics·P D'Orléans-JusteJ C Honoré
Mar 6, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Liping TangMichael B Fallon
Jul 1, 2008·Pharmacology & Therapeutics·Daphne MerkusDirk J Duncker
Oct 3, 1998·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M Albertini, M G Clement
Jun 4, 1998·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M G ClementM Albertini
Mar 11, 2005·Journal of Clinical Gastroenterology·Michael B Fallon
Oct 18, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Daphne MerkusDirk J Duncker
Aug 13, 1999·The American Journal of Physiology·E ThorinM Lavallée

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