Differential representation of auditory categories between cell classes in primate auditory cortex.

The Journal of Physiology
Joji TsunadaYale E Cohen

Abstract

A comprehensive understanding of the neural mechanisms of cognitive function requires an understanding of how neural representations are transformed across different scales of neural organization: from within local microcircuits to across different brain areas. However, the neural transformations within the local microcircuits are poorly understood. Particularly, the role that two main cell classes of neurons in cortical microcircuits (i.e. pyramidal neurons and interneurons) have in auditory behaviour and cognition remains unknown. In this study, we tested the hypothesis that pyramidal cells and interneurons in the auditory cortex play a differential role in auditory categorization. To test this hypothesis, we recorded single-unit activity from the auditory cortex of rhesus monkeys while they categorized speech sounds. Based on the spike-waveform shape, a neuron was classified as either a narrow-spiking putative interneuron or a broad-spiking putative pyramidal neuron. We found that putative interneurons and pyramidal neurons in the auditory cortex differentially coded category information: interneurons were more selective for auditory categories than pyramidal neurons. These differences between cell classes may be an essentia...Continue Reading

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Citations

Mar 22, 2013·Journal of the Association for Research in Otolaryngology : JARO·Margit DyllaRamnarayan Ramachandran
Sep 21, 2013·Nature Reviews. Neuroscience·Jennifer K Bizley, Yale E Cohen
Mar 3, 2015·The European Journal of Neuroscience·Julie E Elie, Frédéric E Theunissen
Apr 12, 2014·Hearing Research·Kate L Christison-LagayYale E Cohen
Aug 8, 2014·Frontiers in Neuroscience·Bethany Plakke, Lizabeth M Romanski
Jun 12, 2014·Frontiers in Neuroscience·Anke LeyElia Formisano
Jul 6, 2014·Frontiers in Neuroscience·Joji Tsunada, Yale E Cohen
Jun 1, 2016·Frontiers in Behavioral Neuroscience·Yan TangLongnian Lin
Jan 29, 2019·PLoS Computational Biology·Margot C Bjoring, C Daniel Meliza
Mar 7, 2017·Frontiers in Neuroscience·Einat Liebenthal, Lynne E Bernstein
Sep 1, 2017·Journal of Neurophysiology·Kate L Christison-LagayYale E Cohen
Jan 16, 2019·Scientific Reports·Richárd FiáthIstván Ulbert

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