Differential requirement for DOCK2 in migration of plasmacytoid dendritic cells versus myeloid dendritic cells

Blood
Kazuhito GotohYoshinori Fukui

Abstract

The migratory properties of dendritic cells (DCs) are important for their functions. Although several chemokines and their receptors have been implicated in DC migration, the downstream signaling molecules are largely unknown. Here we show that DOCK2, a hematopoietic cell-specific CDM family protein, is indispensable for migration of plasmacytoid DCs (pDCs), but not myeloid DCs (mDCs). Although DOCK2-deficiency did not affect development of pDCs, DOCK2-deficient (DOCK2(-/-)) mice exhibited a severe reduction of pDCs in the spleen and lymph nodes. Adoptive transfer experiments revealed that DOCK2(-/-) pDCs failed to migrate into the periarteriolar lymphoid sheaths of the spleen. In DOCK2(-/-) pDCs, chemokine-induced Rac activation was severely impaired, resulting in the reduction of motility and the loss of polarity during chemotaxis. In contrast, DOCK2(-/-) mDCs did not show any defects in Rac activation and migration. These results indicate that pDCs and mDCs use distinct molecules to activate Rac during chemotaxis.

References

Aug 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·G PennaL Adorini
Mar 27, 2002·Nature Reviews. Immunology·Ken Shortman, Yong-Jun Liu
Aug 23, 2002·Trends in Cell Biology·Karin Reif, Jason Cyster
Sep 13, 2002·Immunology and Cell Biology·Lois L Cavanagh, Ulrich H Von Andrian
Nov 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anne KrugMarco Colonna
Nov 19, 2004·Nature Immunology·Marco ColonnaYong-Jun Liu
Aug 3, 2005·The Journal of Experimental Medicine·Hiroyuki YoneyamaKouji Matsushima
Apr 25, 2006·Nature Immunology·Jordi C OchandoJonathan S Bromberg
Sep 1, 2006·The Journal of Cell Biology·Yuya KunisakiYoshinori Fukui
Feb 28, 2007·The Journal of Experimental Medicine·César Nombela-ArrietaJens V Stein

❮ Previous
Next ❯

Citations

Aug 6, 2013·Experimental Cell Research·Akihiko NishikimiYoshinori Fukui
Sep 22, 2011·Nature Immunology·Ioannis Karakasiliotis, Dimitris L Kontoyiannis
Mar 21, 2012·Proceedings of the National Academy of Sciences of the United States of America·Whitney E PurthaDeepta Bhattacharya
Sep 25, 2010·Current Opinion in Allergy and Clinical Immunology·Helen C Su
Jul 7, 2010·Seminars in Immunopathology·Takaharu Okada
Jan 31, 2013·The Journal of Biological Chemistry·Fumiyuki SanematsuYoshinori Fukui
Dec 17, 2009·Autoimmunity·Dilki C WickramarachchiDwight H Kono
Jun 29, 2010·Trends in Immunology·Silvano SozzaniFabio Facchetti
Sep 4, 2009·European Journal of Immunology·Yu LeiYousuke Takahama
Dec 9, 2014·Cell Adhesion & Migration·Silvia M GoicoecheaRafael Garcia-Mata
Jul 16, 2014·European Journal of Cell Biology·Gilles Gadea, Anne Blangy
Apr 20, 2014·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Daifulah Al-ZahraniRaif Geha
Jul 15, 2015·Nature Reviews. Immunology·Melissa Swiecki, Marco Colonna
Jun 18, 2015·The New England Journal of Medicine·Kerry DobbsLuigi D Notarangelo
Oct 14, 2014·Frontiers in Immunology·Takumi Kawasaki, Taro Kawai
Nov 26, 2014·The Journal of Experimental Medicine·Qian ZhangHelen C Su
Jan 1, 2009·Progress in Molecular Biology and Translational Science·Hyeseon Cho, John H Kehrl
Aug 10, 2016·Journal of Cellular Physiology·Xia Guo, Shi-You Chen
Mar 7, 2018·European Journal of Immunology·Yayun ChenZhiping Liu
Jul 18, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Serre-Yu WongKen Cadwell
Apr 13, 2019·Immunological Reviews·Nadine EckertReinhold Förster
Aug 21, 2012·Nature Immunology·Sirish K IppaguntaThirumala-Devi Kanneganti
May 14, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Catherine StevensonMichael R Elliott
Dec 4, 2016·Hematology·Jill M Sullivan, David A Rizzieri
Nov 20, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Vinay S MahajanShiv Pillai
Oct 21, 2019·International Immunology·Kazufumi KunimuraYoshinori Fukui
Jun 4, 2020·Clinical & Translational Immunology·Yishan YeFlorent Malard
Dec 20, 2018·Immunological Reviews·Erin Janssen, Raif S Geha
Dec 29, 2016·The Journal of Biological Chemistry·Akira ShiraishiYoshinori Fukui
Nov 6, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Takeshi YamamotoMakoto Kadowaki
Jul 11, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yue ZhangMakoto Kadowaki
Aug 24, 2021·Frontiers in Immunology·Soichi MizuguchiDongchon Kang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.