PMID: 15240678Jul 9, 2004Paper

Differential requirement for IFN-gamma in CTL maturation in acute murine graft-versus-host disease

The Journal of Immunology : Official Journal of the American Association of Immunologists
Roman PuliaevCharles S Via

Abstract

Although IFN-gamma is the archetypal Th1 cytokine, its role in CTL maturation is uncertain. We used an in vivo mouse model of CTL development, parent-into-F(1) acute graft-vs-host disease (AGVHD), to evaluate this issue. In AGVHD, transfer of naive parental T cells into F(1) hosts stimulates the development of allospecific CTL effectors that eliminate host lymphocytes, particularly B cells. Complete elimination of IFN-gamma, using IFN-gamma-deficient donors and administering anti-IFN-gamma mAb, suppressed B cell elimination, down-regulated TNF-alpha production, and enhanced Th2 cytokine production, but did not allow the B cell expansion characteristic of chronic GVHD (CGVHD). Because complete CTL inhibition results in full-blown CGVHD that is IFN-gamma independent, these observations indicate that IFN-gamma elimination only partially blocks CTL development. IFN-gamma elimination did not inhibit donor T cell engraftment or activation in the AGVHD model, but almost completely blocked Fas/Fas ligand (FasL) gene expression, protein up-regulation, and Fas/FasL-mediated CTL killing. In contrast, IFN-gamma elimination only partially inhibited perforin gene expression and perforin-mediated CTL activity. The contributions of IFN-gamma t...Continue Reading

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Citations

Jun 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Roman PuliaevCharles S Via
Jan 23, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Vinh NguyenVioleta Rus
Jan 19, 2007·Journal of Virology·Isaac G SakalaGunasegaran Karupiah
Feb 19, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ozen SercanThomas Schüler
Oct 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Irina PuliaevaCharles S Via
Nov 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Juyang KimByungsuk Kwon
May 3, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anthony D FosterCharles S Via
Dec 1, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Irina PuliaevaCharles S Via
Jun 27, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Diana RohlmanNancy I Kerkvliet
Mar 26, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kateryna SoloviovaCharles S Via
Mar 16, 2007·British Journal of Haematology·Edward S Morris, Geoffrey R Hill
Mar 2, 2013·PloS One·Ramon M RodriguezCarlos Lopez-Larrea
Jun 19, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Julie M CurtsingerMatthew F Mescher
Mar 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Violeta RusCharles S Via
Apr 5, 2014·European Journal of Immunology·Reece G MarillierJacques Van Snick
Feb 22, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zhiwei XuLaurence Morel
Feb 6, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marie-Eve BlaisClaude Perreault
May 15, 2020·Cellular Immunology·Kateryna SoloviovaCharles S Via
Apr 1, 2017·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Charles S ViaFred D Finkelman
Apr 9, 2021·Cellular Immunology·Rajkumar VenkatadriRahul Sharma

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